ArticleeLife2021
Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration.Nature communications · 2022Trial
- Exposure to broadband noise during non-REM sleep impairs hippocampal sharp-wave ripples and memory consolidation.Current biology : CB · 2026Article
- Learning how to experience the world: From circuits to cell types to genes.Current opinion in neurobiology · 2026Review
- When dreams feel real: the MÖBIUS model.Communications biology · 2026Review
- The medial septum-hippocampus-lateral septum circuitry in spatial memory: linking healthy function to early Alzheimer's disease and translational opportunities.Translational neurodegeneration · 2025Review
- Cholinergic modulation of neural networks supports sequential and complementary roles for NREM and REM states in memory consolidation.PLoS computational biology · 2025Article
- Acetylcholine in the hippocampus: problems and achievements.Frontiers in neural circuits · 2025Review
- Cross-strata co-occurrence of ripples with theta-frequency oscillations in the hippocampus of foraging rats.The Journal of physiology · 2024Article
- Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come.Molecular neurodegeneration · 2023Article
- Article
- Cholinergic Stimulation Modulates the Functional Composition of CA3 Cell Types in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neural ensembles in navigation: From single cells to population codes.Current opinion in neurobiology · 2023Review
- Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer's disease.Scientific reports · 2022Article
- Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review.Journal of Yeungnam medical science · 2022Article
- Multiple-Timescale Representations of Space: Linking Memory to Navigation.Annual review of neuroscience · 2022Review
- Optogenetics: implications for Alzheimer's disease research and therapy.Molecular brain · 2022Review
- Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
The hippocampus plays a central role in long-term memory formation, and different hippocampal network states are thought to have different functions in this process. These network states are controlled by neuromodulatory inputs, including the cholinergic input from the medial septum. Here, we used optogenetic stimulation of septal cholinergic neurons to understand how cholinergic activity affects different stages of spatial memory formation in a reward-based navigation task in mice. We found that optogenetic stimulation of septal cholinergic neurons (1) impaired memory formation when activated at goal location but not during navigation, (2) reduced sharp wave ripple (SWR) incidence at goal location, and (3) reduced SWR incidence and enhanced theta-gamma oscillations during sleep. These results underscore the importance of appropriate timing of cholinergic input in long-term memory formation, which might help explain the limited success of cholinesterase inhibitor drugs in treating memory impairment in Alzheimer's disease.
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