Evidence map›Paper›PMID 33821788›Full record

ArticleeLife2021

Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience.

Alexander Fengler, Lakshmi N Govindarajan, Tony Chen, Michael J Frank

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
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  8. Simulation-based inference captures non-Markovian effects as exemplified in protein production kinetics through cell division.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  13. Learning expectations shape cognitive control allocation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
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  20. Computational Phenotyping of Effort-Based Decision Making in Unmedicated Adults With Remitted Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander FenglerDepartment of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, United States.ORCID 0000-0002-0104-3905
Lakshmi N GovindarajanDepartment of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, United States.ORCID 0000-0002-0936-2919
Tony ChenPsychology and Neuroscience Department, Boston College, Chestnut Hill, United States.
Michael J FrankDepartment of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, United States.ORCID 0000-0001-8451-0523

Funding

Project 4_Bruchas : Circuit-level Approaches for Dissecting Approach/Avoidance Behaviors Mediated by Nociceptin Systems in MiceP50MH119467 · NIMH · MCLEAN HOSPITAL · PI PIZZAGALLI, DIEGO A · 2020 to 2024
$15.9M
Cognitive Neurocomputational Task Reliability and Clinical Applications ConsortiumR01MH084840 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, Cameron S. Carter · 2008 to 2026
$8.5M
NIMH NIH HHS P50 MH119467NIMH NIH HHS R01 MH084840
6 · The paper itself

Abstract

In cognitive neuroscience, computational modeling can formally adjudicate between theories and affords quantitative fits to behavioral/brain data. Pragmatically, however, the space of plausible generative models considered is dramatically limited by the set of models with known likelihood functions. For many models, the lack of a closed-form likelihood typically impedes Bayesian inference methods. As a result, standard models are evaluated for convenience, even when other models might be superior. Likelihood-free methods exist but are limited by their computational cost or their restriction to particular inference scenarios. Here, we propose neural networks that learn approximate likelihoods for arbitrary generative models, allowing fast posterior sampling with only a one-off cost for model simulations that is amortized for future inference. We show that these methods can accurately recover posterior parameter distributions for a variety of neurocognitive process models. We provide code allowing users to deploy these methods for arbitrary hierarchical model instantiations without further training.

Indexed as

CognitionCognitive NeuroscienceModels, NeurologicalNeural Networks, ComputerBayes TheoremBrainComputer SimulationHumansLikelihood FunctionsNeural Pathwaysapproximate bayesian computationcognitive neurosciencecomputational modelshumanmouseneural networksneuroscienceratrhesus macaquesequential sampling models

Identifiers

PMID33821788
PMCPMC8102064

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.