Evidence map›Paper›PMID 33821766›Full record

ArticleThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2021

Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style.

Ruth H Asch, Irina Esterlis, Frank R Wendt, Lorig Kachadourian, Steven M Southwick, Joel Gelernter, Renato Polimanti, Robert H Pietrzak

Open access · greenAbstract read
In one paragraph

Article in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ruth H AschDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-9575-0183
Irina EsterlisDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Frank R WendtDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Lorig KachadourianDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Steven M SouthwickDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Renato PolimantiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Robert H PietrzakDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
United States Department of Veterans Affairs · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
RESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2M
Decoding the Sex-Specific Biological Mechanisms of Psychiatric Disorders Using Genome-Wide AnalysesF32MH122058 · NIMH · YALE UNIVERSITY · PI WENDT, FRANK · 2020 to 2021
$118k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS F32 MH122058NIMH NIH HHS T32 MH014276
6 · The paper itself

Abstract

objectivesTo examine whether attachment style moderates the relationship between polygenic risk scores (PRS) for posttraumatic stress disorder (PTSD) re-experiencing (PTSD

methodsData were analysed from 631 US veterans who endorsed 'unexpected death of a loved one' as their 'worst' traumatic event. Multivariable models evaluated the association between PRS for PTSD

resultsPTSD

conclusionsHaving a secure attachment style may help mitigate polygenic risk for developing traumatic loss-related PTSD in US veterans. Podosomes, which are implicated in inflammatory and neuroplasticity processes, may contribute to the genetic liability to developing loss-related PTSD. Psychological treatments targeting attachment security may help mitigate increased polygenic risk for loss-related PTSD in this population.

Indexed as

Military PersonnelStress Disorders, Post-TraumaticVeteransHumansMultifactorial Inheritancebereavementgene–environment interactionposttraumatic stress disorder (PTSD)Veterans

Identifiers

PMID33821766
PMCPMC8925016
OpenAlexW3148219258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.