Evidence map›Paper›PMID 33821688›Full record

ArticleJournal of the American Heart Association2021

Association of Pro-B-Type Natriuretic Peptide With Cardiac Magnetic Resonance-Measured Global and Regional Cardiac Function and Structure Over 10 Years: The MESA Study.

Amir Ali Rahsepar, David A Bluemke, Mohammadali Habibi, Kiang Liu, Nadine Kawel-Boehm, Bharath Ambale-Venkatesh, Veronica R S Fernandes, Boaz D Rosen, Joao A C Lima, James C Carr

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Amir Ali RahseparDepartment of Radiology Feinberg School of Medicine Northwestern University Chicago IL.
David A BluemkeDepartment of Radiology University of Wisconsin, School of Medicine and Public Health Madison WI.
Mohammadali HabibiDepartment of Cardiology Johns Hopkins University Baltimore MD.
Kiang LiuDepartment of Preventive Medicine Feinberg School of Medicine Northwestern University Chicago IL.
Nadine Kawel-BoehmDepartment of Radiology Kantonsspital Graubuenden Chur Switzerland.
Bharath Ambale-VenkateshDepartment of Cardiology Johns Hopkins University Baltimore MD.
Veronica R S FernandesDepartment of Cardiology Johns Hopkins University Baltimore MD.
Boaz D RosenDepartment of Cardiology Johns Hopkins University Baltimore MD.
Joao A C LimaDepartment of Cardiology Johns Hopkins University Baltimore MD.
James C CarrDepartment of Radiology Feinberg School of Medicine Northwestern University Chicago IL.
Johns Hopkins University · USNorthwestern University · USUniversity of Bern · CHUniversity of Wisconsin–Madison · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
CARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4M
NCATS COLLABORATIVE SCIENTIFIC PLATFORM AS A SERVICE CONTINUATION - COVID-19 DATASET AGGREGATION PROOF OF CONCEPT75N95020D00003 · NIDA · PALANTIR TECHNOLOGIES INC. · PI BUSH, JULIE · 2020 to 2020
$2.0M
UNSPECIFIED [24-000022]75N95020D00002 · NIDA · NATIONAL MEDICAL SERVICES, INC. · PI BLUM, LEE · 2020 to 2024
$1.5M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
CLC NIH HHS 75N90020D00002CLC NIH HHS 75N90020D00003NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NIAID NIH HHS 75N93020D00002NIDA NIH HHS 75N95020D00002NIDA NIH HHS 75N95020D00003NIDA NIH HHS 75N95020D00004NIDA NIH HHS 75N95020D00005NIDA NIH HHS 75N95020D00007NIEHS NIH HHS 75N96020D00002NIEHS NIH HHS 75N96020D00003NIH HHS 75N98020D00007ORFDO NIH HHS 75N99020D00002ORFDO NIH HHS 75N99020D00003ORFDO NIH HHS 75N99020D00004ORFDO NIH HHS 75N99020D00005ORFDO NIH HHS 75N99020D00006ORFDO NIH HHS 75N99020D00007
6 · The paper itself

Abstract

Background NT-proBNP (N-terminal pro-B-type natriuretic peptide) is widely used to diagnose and manage patients with heart failure. We aimed to investigate associations between NT-proBNP levels and development of global and regional myocardial impairment, dyssynchrony, and risk of developing myocardial scar over time. Methods and Results We included 2416 adults (45-84 years) without baseline clinical cardiovascular disease from MESA (Multi-Ethnic Study of Atherosclerosis). NT-proBNP was assessed at baseline (2000-2002). Cardiac magnetic resonance-measured left ventricular parameters were assessed at baseline and year 10 (2010-2012). Tagged cardiac magnetic resonance and myocardial dyssynchrony were assessed. We used linear and logistic regression models to study the relationships between quartiles of NT-proBNP levels and outcome variables. Left ventricular parameters decreased over time. After 10-year follow-up and adjusting for cardiovascular disease risk factors, people in the highest quartile had significantly greater decline in left ventricular ejection fraction (-1.60%; 95% CI, -2.26 to -0.94;

Indexed as

ForecastingAgedAged, 80 and overBiomarkersFemaleFollow-Up StudiesHeart VentriclesHumansMagnetic Resonance Imaging, CineMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsPopulation SurveillanceProspective StudiesRisk FactorsBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)cardiac magnetic resonance imaginglongitudinal studyNT‐proBNPscar

Identifiers

PMID33821688
PMCPMC8174164
OpenAlexW3140856198

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.