Evidence map›Paper›PMID 33821682›Full record

ArticleJournal of the American Heart Association2021

Short-Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4-Dimensional-Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension.

Michal Schäfer, Benjamin S Frank, D Dunbar Ivy, Steven H Abman, Kurt R Stenmark, Max B Mitchell, Lorna P Browne, Alex J Barker, Kendall S Hunter, Vitaly Kheyfets and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Characterization of pulmonary arterial stiffness using cardiac MRI.The international journal of cardiovascular imaging · 2024
    Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Michal SchäferDivision of Cardiology Heart Institute Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Benjamin S FrankDivision of Cardiology Heart Institute Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
D Dunbar IvyDivision of Cardiology Heart Institute Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Steven H AbmanDivision of Pulmonology Breathing Institute Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Kurt R StenmarkDepartment of Critical Care and Pulmonary Medicine University of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Max B MitchellSection of Congenital Heart Surgery Heart Institute Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Lorna P BrowneDepartment of Radiology Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Alex J BarkerDepartment of Radiology Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Kendall S HunterDepartment of Radiology Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Vitaly KheyfetsDepartment of Bioengineering University of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Kathleen Miller-ReedDivision of Cardiology Heart Institute Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Richard IngDepartment of Anesthesiology Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Gareth J MorganDivision of Cardiology Heart Institute Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Uyen TruongDivision of Cardiology Heart Institute Children's Hospital ColoradoUniversity of Colorado DenverAnschutz Medical Campus Aurora CO USA.
Children's Hospital Colorado · USUniversity of Colorado Anschutz Medical Campus · USVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Pulmonary arterial hypertension (PAH) manifests with progressive right ventricular (RV) dysfunction, which eventually impairs the left ventricular function. We hypothesized that 4-dimensional-flow magnetic resonance imaging can detect flow hemodynamic changes associated with efficient intracardiac flow during noninvasive inhaled nitric oxide (iNO) challenge in children with PAH. Methods and Results Children with PAH (n=10) underwent 2 same-day separate iNO challenge tests using: (1) 4-dimensional-flow magnetic resonance imaging and (2) standard catheterization hemodynamics. Intracardiac flow was evaluated using the particle tracking 4-flow component analysis technique evaluating the

Indexed as

Administration, InhalationAdolescentChildChild, PreschoolEndothelium-Dependent Relaxing FactorsFemaleFollow-Up StudiesHeart VentriclesHemodynamicsHumansImage Processing, Computer-AssistedInfantMagnetic Resonance Imaging, CineMaleNitric OxideProspective StudiesEndothelium-Dependent Relaxing FactorsNitric Oxideintracardiac flownitric oxidepulmonary hypertension

Identifiers

PMID33821682
PMCPMC8174179
OpenAlexW3143548970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.