ArticleAngewandte Chemie (International ed. in English)2021
Tuneable Control of Organocatalytic Activity through Host-Guest Chemistry.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Light-Induced Anion Translocation to Control Helical Folding in an Artificial Communication System.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- A novel biomacromolecule-predominated hybrid unit: from design, characterization to application.National science review · 2026Article
- Regulation of microtubule dynamics and function in living cellsChemical science · 2024Article
- Chemical reaction networks based on conjugate additions on β'-substituted Michael acceptors.Chemical communications (Cambridge, England) · 2023Review
- Transient Host-Guest Complexation To Control Catalytic Activity.Journal of the American Chemical Society · 2022Article
- Temporal Control of the Host-Guest Properties of a Calix[6]arene Receptor by the Use of a Chemical Fuel.The Journal of organic chemistry · 2022Article
- Tuneable Control of Organocatalytic Activity through Host-Guest Chemistry.Angewandte Chemie (International ed. in English) · 2021Article
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11 authors.
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Abstract
Dynamic regulation of chemical reactivity is important in many complex chemical reaction networks, such as cascade reactions and signal transduction processes. Signal responsive catalysts could play a crucial role in regulating these reaction pathways. Recently, supramolecular encapsulation was reported to regulate the activities of artificial catalysts. We present a host-guest chemistry strategy to modulate the activity of commercially available synthetic organocatalysts. The molecular container cucurbit[7]uril was successfully applied to change the activity of four different organocatalysts and one initiator, enabling up- or down-regulation of the reaction rates of four different classes of chemical reactions. In most cases CB[7] encapsulation results in catalyst inhibition, however in one case catalyst activation by binding to CB[7] was observed. The mechanism behind this unexpected behavior was explored by NMR binding studies and pKa measurements. The catalytic activity can be instantaneously switched during operation, by addition of either supramolecular host or competitive binding molecules, and the reaction rate can be predicted with a kinetic model. Overall, this signal responsive system proves a promising tool to control catalytic activity.
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