ReviewBiological reviews of the Cambridge Philosophical Society2021
What can we teach Lymnaea and what can Lymnaea teach us?
Review in Biological reviews of the Cambridge Philosophical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 56 citations in OpenAlex.
- First evidence of an anxiety-like behavior and its pharmacological modulation in a molluscan model organism, Lymnaea stagnalis.Translational psychiatry · 2025Article
- Functional mapping of the molluscan brain guided by synchrotron X-ray tomography.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The genome of the simultaneously hermaphroditic snail Lymnaea stagnalis reveals an evolutionary expansion of FMRFamide-like receptors.Scientific reports · 2024Article
- Same same, but different: exploring the enigmatic role of the pituitary adenylate cyclase-activating polypeptide (PACAP) in invertebrate physiology.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Long-term anti-predator learning and memory differ across populations and sexes in an intertidal snail.Proceedings. Biological sciences · 2024Article
- Lack of membrane sex steroid receptors for mediating rapid endocrine responses in molluscan nervous systems.Frontiers in endocrinology · 2024Article
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- A circuit mechanism linking past and future learning through shifts in perception.Science advances · 2023Article
- A novel and unique refraction-based optical recording system for pharmacological investigations on isolated muscle preparations.MethodsX · 2023Article
- Identification and characterization of the kynurenine pathway in the pond snail Lymnaea stagnalis.Scientific reports · 2022Article
- A flavonoid, quercetin, is capable of enhancing long-term memory formation if encountered at different times in the learning, memory formation, and memory recall continuum.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- The role of non-coding RNAs in the formation of long-term associative memory after single-trial learning inFrontiers in behavioral neuroscience · 2022Review
- Insulin and Memory in Invertebrates.Frontiers in behavioral neuroscience · 2022Review
- Studies on a widely-recognized snail model species (Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review describes the advantages of adopting a molluscan complementary model, the freshwater snail Lymnaea stagnalis, to study the neural basis of learning and memory in appetitive and avoidance classical conditioning; as well as operant conditioning of its aerial respiratory and escape behaviour. We firstly explored 'what we can teach Lymnaea' by discussing a variety of sensitive, solid, easily reproducible and simple behavioural tests that have been used to uncover the memory abilities of this model system. Answering this question will allow us to open new frontiers in neuroscience and behavioural research to enhance our understanding of how the nervous system mediates learning and memory. In fact, from a translational perspective, Lymnaea and its nervous system can help to understand the neural transformation pathways from behavioural output to sensory coding in more complex systems like the mammalian brain. Moving on to the second question: 'what can Lymnaea teach us?', it is now known that Lymnaea shares important associative learning characteristics with vertebrates, including stimulus generalization, generalization of extinction and discriminative learning, opening the possibility to use snails as animal models for neuroscience translational research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.