Evidence map›Paper›PMID 33821503›Full record

ArticleThe EMBO journal2021

Mycobiota dysbiosis: a new nexus in intestinal tumorigenesis.

Nicolas Papon, Gordon D Brown, Neil A R Gow

Open access · greenAbstract readComment
In one paragraph

Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Nicolas PaponHost-Pathogen Interaction Study Group (GEIHP, EA 3142), UNIV Angers, UNIV Brest, Angers, France.
Gordon D BrownMedical Research Council Centre for Medical Mycology at the University of Exeter, Exeter, UK.
Neil A R GowMedical Research Council Centre for Medical Mycology at the University of Exeter, Exeter, UK.
Medical Research Council · GBUniversité d'Angers · FR

Funding

Medical Research Council MR/N006364/2Medical Research Council MR/V033417/1Wellcome Trust 102705/Z/13/Z
6 · The paper itself

Abstract

While there is growing evidence that perturbation of the gut microbiota can result in a variety of pathologies including gut tumorigenesis, the influence of commensal fungi remains less clear. In this issue, Zhu et al (2021) show that mycobiota dysbiosis stimulates energy metabolism changes in subepithelial macrophages promoting colon cancer via enhancing innate lymphoid cell activity. These findings provide insights into a role of the gut flora in intestinal carcinogenesis and suggest opportunities for adjunctive antifungal or immunotherapeutic strategies to prevent colorectal cancer.

Indexed as

DysbiosisGastrointestinal MicrobiomeCarcinogenesisHumansImmunity, InnateLymphocytes

Identifiers

PMID33821503
PMCPMC8167357
OpenAlexW3146869186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.