Evidence map›Paper›PMID 33821502›Full record

ArticleMagnetic resonance in medicine2021

Long-term behavioral effects observed in mice chronically exposed to static ultra-high magnetic fields.

Ivan Tkáč, Michael A Benneyworth, Tessa Nichols-Meade, Elizabeth L Steuer, Sarah N Larson, Gregory J Metzger, Kâmil Uğurbil

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Magnetic resonance imaging.Science advances · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ivan TkáčCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-5054-0150
Michael A BenneyworthMouse Behavioral Core, Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-9574-3939
Tessa Nichols-MeadeMouse Behavioral Core, Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
Elizabeth L SteuerN Bud Grossman Center for Memory Research & Care, Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Sarah N LarsonCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.
Gregory J MetzgerCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-3187-6529
Kâmil UğurbilCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-8475-9334

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Mehmet Akcakaya · 2019 to 2026
$11.7M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
NIBIB NIH HHS P41 EB015894NIBIB NIH HHS P41 EB027061NIH HHS P30-NS076408NIH HHS P41-EB015894NIH HHS P41-EB027061NINDS NIH HHS P30 NS076408
6 · The paper itself

Abstract

purposeThe primary goal of this study was to investigate whether chronic exposures to ultra-high B

methodsC57BL/6 mice were chronically exposed to 10.5-T or 16.4-T magnetic fields (3-h exposures, two exposure sessions per week, 4 or 8 weeks of exposure). In vivo single-voxel

resultsHippocampal neurochemical profile, cognitive, and basic motor functions were not impaired by chronic magnetic field exposures. However, the balance-beam-walking test and the Morris water-maze testing revealed B

conclusionObserved results suggest that the chronic exposure to a magnetic field as high as 16.4 T may result in long-term impairment of the vestibular system in mice. Although observation of mice may not directly translate to humans, nevertheless, they indicate that studies focused on human safety at very high magnetic fields are necessary.

Indexed as

Conditioning, PsychologicalMotor ActivityAnimalsBehavior, AnimalMagnetic FieldsMiceMice, Inbred C57BLbattery of behavioral testschronic exposureneurochemical profilingtight circlingultra-high magnetic fieldsvestibular system

Identifiers

PMID33821502
PMCPMC8569931

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.