Evidence map›Paper›PMID 33821430›Full record

ArticleUpdates in surgery2021

Micronvasive behaviour of single small hepatocellular carcinoma: which treatment?

Roberto Santambrogio, Matteo Barabino, Valentina D'Alessandro, Giulio Iacob, Enrico Opocher, Marco Gemma, Marco Antonio Zappa

Abstract read
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In one paragraph

Article in Updates in surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Roberto SantambrogioASST Fatebenefratelli Sacco, Chirurgia Generale Ospedale Fatebenefratelli, Piazza Principessa Clotilde 3, 20121, Milano, Italy. rsantambrogio@mclink.it.ORCID http://orcid.org/0000-0002-2310-0966
Matteo BarabinoChirurgia Epato-Bilio-Pancreatica Ospedale San Paolo Università Di Milano, Milano, Italy.
Valentina D'AlessandroASST Fatebenefratelli Sacco, Chirurgia Generale Ospedale Fatebenefratelli, Piazza Principessa Clotilde 3, 20121, Milano, Italy.
Giulio IacobASST Fatebenefratelli Sacco, Chirurgia Generale Ospedale Fatebenefratelli, Piazza Principessa Clotilde 3, 20121, Milano, Italy.
Enrico OpocherChirurgia Epato-Bilio-Pancreatica Ospedale San Paolo Università Di Milano, Milano, Italy.
Marco GemmaAnestesia E Rianimazione Ospedale Fatebenefratelli, Milano, Italy.
Marco Antonio ZappaASST Fatebenefratelli Sacco, Chirurgia Generale Ospedale Fatebenefratelli, Piazza Principessa Clotilde 3, 20121, Milano, Italy.
ASST Fatebenefratelli Sacco · ITAzienda Ospedaliera Fatebenefratelli e Oftalmico · ITOspedale San Paolo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicroinvasion (MI), defined as infiltration of the portal or hepatic vein or bile duct and intrahepatic metastasis are accurate indicators of a poor prognosis for mall hepatocellular carcinomas (HCC). A previous study showed that intraoperative ultrasound (IOUS) definition of MI-HCC had a high concordance with histological findings. Aim of this study is to evaluate overall survival and recurrence patterns of patients with MI-HCC submitted to hepatic resection (HR) or laparoscopic ablation therapies (LAT).

methodsA total of 171 consecutive patients (78 h; 93 LAT) with single, small HCC (< 3 cm) with a MI pattern at IOUS examination were compared analyzing overall survival and recurrence patterns using univariate and multivariate analysis and weighting by propensity score.

resultsOverall recurrences were similar in the 2 groups (HR: 51 patients (65%); LAT: 66 patients (71%)). The rate of local tumor progression in the HR group was very low (5 pts; 6%) in comparison to LAT group (22 pts; 24%; p = 0.002). The overall survival curves of HR are significantly better than that of the LAT group (p = 0.0039). On the propensity score Cox model, overall mortality was predicted by the surgical treatment with a Hazard ratio 1.68 (1.08-2.623) (p = 0.022).

conclusionsIf technically feasible and in patients fit for surgery, HR with an adequate tumor margin should be preferred to LAT in patients with MI-HCC at IOUS evaluation, to eradicate MI features near the main nodule, which are relatively frequent even in small HCC (< 3 cm).

Indexed as

Carcinoma, HepatocellularCatheter AblationLiver NeoplasmsHepatectomyHumansNeoplasm Recurrence, LocalProportional Hazards ModelsRetrospective StudiesTreatment OutcomeUltrasonographyHepatic resectionHepatocellular carcinomaLiver cirrhosisLiver transplantationRadiofrequency ablationVascular microinfiltration

Identifiers

PMID33821430
OpenAlexW3150056966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.