ArticleJournal of assisted reproduction and genetics2021
Decreased number of p16-positive senescent cells in human endometrium as a marker of miscarriage.
Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Age-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Implantation Outcome-Specific Associations Between Stromal Senescence and the Endometrial Microbiota.Microorganisms · 2026Article
- Cellular senescence-related gene variants as risk factors for recurrent pregnancy loss.Molecular biology reports · 2026Article
- Disrupted immune senescence in early pregnancy is associated with recurrent pregnancy loss.Frontiers in immunology · 2026Article
- Endometrial Cell Senescence and Recurrent Spontaneous Abortion: Biomarker Potential of UCP2 and GSR.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Spatial Distribution of Senescent Cells and Their Proximity to Immune Subsets in the Human Endometrium During the Implantation Window.Diagnostics (Basel, Switzerland) · 2025Article
- Age-Related Dynamics in Endometrial Vascularity: A Comprehensive Three-Dimensional Ultrasound Evaluation During Follicular and Luteal Phases.Journal of clinical medicine · 2025Article
- Causal Effects of Immune Cells on Reproductive Ill-Health, Including Abnormal Spermatozoa, Polycystic Ovary Syndrome and Spontaneous Abortion: Mendelian Randomization Analyses.Journal of multidisciplinary healthcare · 2025Article
- Cellular Senescence in Endometrium: A Pivotal Regulator in Physiological Remodeling and Pathological Disorders.International journal of biological sciences · 2025Review
- NOTCH1- and CD117-Positive Stem Cells in Human Endometriosis and Adenomyosis Lesions.Diagnostics (Basel, Switzerland) · 2024Article
- Aging promotes accumulation of senescent and multiciliated cells in human endometrial epithelium.Human reproduction open · 2024Article
- Association between endometrial senescent cells and immune cells in women with repeated implantation failure.Journal of assisted reproduction and genetics · 2023Article
- SIRT1 upregulation promotes epithelial-mesenchymal transition by inducing senescence escape in endometriosis.Scientific reports · 2022Article
- The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis.Cells · 2022Review
- Altered p16International journal of molecular sciences · 2022Article
- Deciphering the endometrial immune landscape of RIF during the window of implantation from cellular senescence by integrated bioinformatics analysis and machine learning.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to evaluate whether the number of p16-positive cells in the functional layer of the endometrium could be a useful biomarker to identify women with recurrent implantation failure (RIF) undergoing in vitro fertilization (IVF) at risk of miscarriage.
methodsImmunohistochemical staining was performed in 311 endometrial biopsies taken during mid-luteal phase using antibody against p16
resultsWe found that the percentages of p16-positive glandular and luminal epithelial endometrial cells were significantly higher in patients with live births compared to women with miscarriage (9.3% vs. 2.9%, P < 0.001; and 35.2% vs. 11.7%, P = 0.001, respectively). This tendency was not confirmed in thе stroma. The cut-off values with p16-positive luminal cells lower than 12.5% and p16-positive glandular cells lower than 3.2% could be predictive factors for miscarriage (AUC 0.80 and 0.79; sensitivity 71.3% and 74.5%; specificity 74.2% and 71.2%, respectively).
conclusionA decreased number of senescent p16-positive cells could be involved in the implantation failures and aetiology of recurrent miscarriage. Women with history of RIF with reduced populations of p16-positive cells in the endometrial glandular and luminal epithelium may be at greater risk for unsuccessful implantation and miscarriage. The percentage of p16-positive luminal epithelial cells may be clinically useful as a biomarker of miscarriage.
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