Evidence map›Paper›PMID 33821355›Full record

ArticleLung2021

Evaluation and Management Outcomes and Burdens in Patients with Refractory Chronic Cough Referred for Behavioral Cough Suppression Therapy.

Laurie J Slovarp, Marie E Jetté, Amanda I Gillespie, Jane E Reynolds, Julie M Barkmeier-Kraemer

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Lung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07070895 (A Prospective Decentralized Investigation of the Effect of a Cough Management Feature Inside a Wellness Application), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07070895 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Prospective Decentralized Investigation of the Effect of a Cough Management Feature Inside a Wellness Application (CoughPro) in Refractory or Unexplained Chronic Cough (RCC/UCC)

TypeinterventionalSponsorHyfe IncRan2025 to 2025Enrolled20ConditionsRefractory Chronic Cough, Unexplained Chronic Cough, Cough HypersensitivityArmsCough Management, CoughMonitor Suite
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  13. Increased Resistance of the Peripheral Airways in Patients with Unexplained Chronic Cough.Respiration; international review of thoracic diseases · 2025
    Article
  14. Chronic cough as a disease.ERJ open research · 2024
    Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Laurie J SlovarpSchool of Speech, Language, Hearing, & Occupational Sciences, University of Montana, 32 Campus Dr., Missoula, MT, USA. laurie.slovarp@umontana.edu.ORCID 0000-0002-3547-4092
Marie E JettéDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Amanda I GillespieDepartment of Otolaryngology, Emory University School of Medicine, Atlanta, GA, USA.
Jane E ReynoldsSchool of Speech, Language, Hearing, & Occupational Sciences, University of Montana, 32 Campus Dr., Missoula, MT, USA.
Julie M Barkmeier-KraemerDepartment of Otolaryngology, University of Utah School of Medicine, Salt Lake City, UT, USA.
University of Montana · USEmory University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Utah · US

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Jeffrey Good · 2012 to 2026
$60.0M
Tracking and EvaluationU54GM104944 · NIGMS · UNIVERSITY OF NEVADA LAS VEGAS · PI ZHU, YILIANG · 2013 to 2023
$39.6M
NIGMS NIH HHS P20 GM103474NIGMS NIH HHS U54 GM104944
6 · The paper itself

Abstract

purposeThe purpose of this study was to investigate the typical symptoms and medical management characteristics of adult patients with refractory chronic cough (RCC) who are referred to speech-language pathology (SLP) for behavioral cough suppression therapy (BCST) in order to estimate cost-effectiveness and efficiency of current practice patterns for this population.

methodsOne hundred sixty-four (164) patients with RCC referred for BCST were surveyed. Patients completed an initial survey at BCST onset related to symptom pattern and prior treatment, including the Leicester Cough Questionnaire (LCQ). Every four to six weeks patients completed follow-up surveys to assess their response to BCST.

resultsMean age was 58 years (83.5% women). The majority of patients reported their cough began two or more years prior to BCST. Approximately half (49%) reported seeing four or more physicians (including primary care physicians) and being prescribed four or more medications (57%) prior to BCST. Medications targeting post-nasal drip (72%), reflux (70%), asthma (56%), and allergies (56%) were most commonly prescribed. BCST resulted in a clinically significant improvement in 70.1% of participants. The mean change in LCQ for those who improved with BCST was 6.61. Over half (58%) reported they were quite satisfied to completely satisfied with their treatment response. The average time from enrollment to study completion was 64 days.

conclusionThe results of this study suggest early intervention with BCST may be a cost-effective and efficient option for patients with RCC.

Indexed as

Cost of IllnessDisease ManagementSurveys and QuestionnairesAdolescentAdultAgedAged, 80 and overChronic DiseaseCognitive Behavioral TherapyCost-Benefit AnalysisCoughFemaleHumansMaleMiddle AgedQuality of LifeBehavioral cough suppression therapy (BCST)Chronic coughCost-effectivenessRefractory chronic cough (RCC)Speech-language-pathology (SLP)

Identifiers

PMID33821355
PMCPMC8203529
OpenAlexW3143665842

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.