ArticleEuropean radiology2021
The prognostic role of CMR using global planimetric criteria in patients with excessive left ventricular trabeculation.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review.Heart failure reviews · 2022Pooled it
- The spongy heart paradox: balancing bleeding and clotting risk in left ventricular noncompaction cardiomyopathy.Heart failure reviews · 2026Review
- Double-Chambered Left Ventricle: How Cardiac Magnetic Resonance Overturned the Diagnosis.JACC. Case reports · 2025Article
- Prognostic Value of Compact Myocardial Thinning in Patients With Left Ventricular Noncompaction.The American journal of cardiology · 2025Article
- Role of Imaging in Cardiomyopathies.Cardiac failure review · 2023Review
- Higher spatial resolution improves the interpretation of the extent of ventricular trabeculation.Journal of anatomy · 2022Article
- Ventricular arrhythmia management in patients with genetic cardiomyopathies.Heart rhythm O2 · 2021Article
- Diagnosing excessive trabeculation cardiomyopathy: in pursuit of the "holy grail".European radiology · 2021Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAlthough cardiovascular magnetic resonance (CMR) is widely used in the assessment of left ventricular non-compaction (LVNC), there are no universally accepted diagnostic criteria and limited data regarding their prognostic value. We assessed the long-term prognostic role of the planimetric global Grothoff's criteria and of the CMR findings in predicting adverse cardiovascular events (CE).
methodsWe prospectively enrolled 78 patients (46.7 ± 18.7 years, 33.3% females) with documented positive Jenni's echocardiographic criteria for LVNC. Cine images were used to quantify function parameters and to assess for the presence of all four quantitative Grothoff's criteria (global Grothoff's criteria). Late gadolinium enhancement (LGE) images were acquired to detect the presence of replacement myocardial fibrosis.
resultsPetersen's CMR criterion for LVNC (NC/C ratio > 2.3 in at least one myocardial segment) was fulfilled in the whole population. Twenty-six patients fulfilled the global Grothoff's criteria (four out of four). The mean duration of the follow-up was 44.2 ± 27.4 months and 28 CE were registered: 10 ventricular tachycardias, 12 episodes of heart failure (HF), four strokes, and two cardiac deaths. In the multivariate analysis, the independent predictive factors for CE were positive global Grothoff's criteria (hazard ratio, HR = 3.33, 95% CI = 1.52-7.29; p = 0.003) and myocardial fibrosis (HR = 2.41, 95% CI = 1.08-5.36; p = 0.032).
conclusionsPositive global Grothoff's criteria and myocardial fibrosis were powerful predictors of CE in patients with a diagnosis of LVNC by CMR Petersen's criterion. Thus, we strongly suggest a step approach confirming the diagnosis of LVNC by using the global planimetric Grothoff's criteria, which showed a prognostic impact. KEY POINTS: • Positive global Grothoff's criteria and replacement myocardial fibrosis were powerful predictors of cardiovascular events in patients with a diagnosis of LVNC by CMR Petersen's criterion. • Positive global Grothoff's criteria were associated with a higher frequency of ventricular arrhythmias in patients with a diagnosis of LVNC by CMR Petersen's criterion.
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