Evidence map›Paper›PMID 33821331›Full record

ArticleBiomedical microdevices2021

3D printed alginate bead generator for high-throughput cell culture.

Donghee Lee, Sydney E Greer, Mitchell A Kuss, Yang An, Andrew T Dudley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical microdevices, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Augmented 3D Printing for Multiscale Microphysiological Systems.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Donghee LeeDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Sydney E GreerDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Mitchell A KussDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yang AnCheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Andrew T DudleyDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA. andrew.dudley@unmc.edu.ORCID 0000-0001-9512-8725

Funding

Cell biological mechanisms that regulate development of cartilage architectureR01AR070242 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DUDLEY, ANDREW T · 2016 to 2020
$1.7M
NIAMS NIH HHS AR070242NIAMS NIH HHS R01 AR070242
6 · The paper itself

Abstract

Alginate hydrogel beads are a common platform for generating 3D cell cultures in biomedical research. Simple methods for bead generation using a manual pipettor or syringe are low-throughput and produce beads showing high variability in size and shape. To address these challenges, we designed a 3D printed bead generator that uses an airflow to cleave beads from a stream of hydrogel solution. The performance of the proposed alginate bead generator was evaluated by changing the volume flow rates of alginate (Q

Indexed as

AlginatesCell Culture TechniquesHydrogelsPrinting, Three-DimensionalAlginatesHydrogels3D cell culture3D printingAlginate hydrogelChondrocytesDroplet generator

Identifiers

PMID33821331
PMCPMC8312329

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.