Evidence map›Paper›PMID 33821323›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2021

Clinical response in patients treated with once-monthly paliperidone palmitate: analysis of a therapeutic drug monitoring (TDM) database.

Georgios Schoretsanitis, Ekkehard Haen, Daria Piacentino, Andreas Conca, Katharina Endres, Christoph Hiemke, Gerhard Gründer, Michael Paulzen

Abstract read
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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Georgios SchoretsanitisThe Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Behavioral Health Pavilion, 7559 263rd Street, Glen Oaks, NY, 11004, USA. george.schor@gmail.com.ORCID http://orcid.org/0000-0002-3851-4117
Ekkehard HaenClinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.
Daria PiacentinoPsychiatric Service of the Health District of Bozen, Bozen, Italy.
Andreas ConcaPsychiatric Service of the Health District of Bozen, Bozen, Italy.
Katharina EndresClinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.
Christoph HiemkeDepartment of Psychiatry and Psychotherapy and Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of Mainz, Mainz, Germany.
Gerhard GründerDepartment of Molecular Neuroimaging, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Michael PaulzenAlexianer Hospital Aachen, Aachen, Germany.
University of Regensburg · DEHeidelberg University · DEJohannes Gutenberg University Mainz · DEJülich Aachen Research Alliance · DENational Institute on Drug Abuse · USNorthwell Health · USOspedale di Bolzano · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate pharmacokinetic correlates of clinical response in patients treated with once-monthly paliperidone palmitate (PP1M) injections at steady state. Plasma concentrations and dose-adjusted-plasma concentrations (C/D) of paliperidone from a naturalistic therapeutic drug monitoring (TDM) database were compared between responders and non-responders using the Clinical Global Impressions-Improvement scale (CGI-I) ratings. Analyses were based on the non-parametric Mann-Whitney U test and the Pearson Chi-squared test (χ

Indexed as

Antipsychotic AgentsDrug MonitoringPaliperidone PalmitateBipolar DisorderDrug Administration ScheduleFemaleHumansMalePsychotic DisordersSchizophreniaTreatment OutcomeAntipsychotic AgentsPaliperidone PalmitateAntipsychoticsClinical responsePaliperidone palmitatePharmacokineticsPsychopharmacologyTherapeutic drug monitoring (TDM)

Identifiers

PMID33821323
OpenAlexW3143639127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.