Evidence map›Paper›PMID 33821285›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Circadian immunity, sunrise time and the seasonality of respiratory infections.

Ziyi Mo, Armin Scheben, Joshua Steinberg, Adam Siepel, Robert Martienssen

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ziyi MoSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
Armin SchebenSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
Joshua SteinbergMedical Scientist Training Program (MSTP), Renaissance School of Medicine at Stony Brook University, Stony Brook, NY.
Adam SiepelSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
Robert MartienssenHoward Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Cold Spring Harbor Laboratory · USHoward Hughes Medical Institute · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008444 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI FROHMAN, MICHAEL A. · 1992 to 2024
$12.6M
Evolutionary Human Genomics: Demography, Natural Selection, and Transcriptional RegulationR35GM127070 · NIGMS · COLD SPRING HARBOR LABORATORY · PI Adam Charles Siepel · 2018 to 2026
$4.7M
NIGMS NIH HHS R35 GM127070NIGMS NIH HHS T32 GM008444
6 · The paper itself

Abstract

The innate and adaptive immune response are regulated by biological clocks, and circulating lymphocytes are lowest at sunrise. Accordingly, severity of disease in mouse models is highly dependent on the time of day of viral infection. Here, we explore whether circadian immunity contributes significantly to seasonality of respiratory viruses, including influenza and SARS-CoV-2. Susceptibility-Infection-Recovery-Susceptibility (SIRS) models of influenza and SIRS-derived models of COVID-19 suggest that local sunrise time is a better predictor of the basic reproductive number (

Identifiers

PMID33821285
PMCPMC8020986
OpenAlexW3152228906

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.