Evidence map›Paper›PMID 33821233›Full record

ArticleCell stress2021

Inhibitory DAMPs in immunogenic cell death and its clinical implications.

Kazukuni Hayashi, Fotis Nikolos, Keith S Chan

Open access · goldAbstract readComment
In one paragraph

Article in Cell stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  8. Article
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  11. Resolution Potential of Necrotic Cell Death Pathways.International journal of molecular sciences · 2022
    Review
  12. Immunogenic Cell Death Role in Urothelial Cancer Therapy.Current oncology (Toronto, Ont.) · 2022
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kazukuni HayashiDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Fotis NikolosSamuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Keith S ChanDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Cedars-Sinai Medical Center · USBaylor College of Medicine · US

Funding

Training Program in Translational Biology and Molecular MedicineT32GM088129 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI ROONEY, CLIONA M., VAN DEN VEYVER, IGNATIA B · 2010 to 2019
$3.0M
Targeting tumor repopulation and the immune microenvironment to overcome chemoresistanceR01CA255609 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHAN, KEITH SYSON · 2021 to 2025
$2.2M
Regulation of inhibitory DAMP to harness immunogenic cell deathF31CA247257 · NCI · CEDARS-SINAI MEDICAL CENTER · PI HAYASHI, KAZUKUNI · 2020 to 2022
$116k
NCI NIH HHS F31 CA247257NCI NIH HHS R01 CA255609NIGMS NIH HHS T32 GM088129
6 · The paper itself

Abstract

Dying (or dead) cells are increasingly recognized to impose significant biological influence within their tissues of residence-exerting paracrine effects through proteins and metabolites that are expressed or secreted during cellular demise. For example, certain molecules function as potent mitogens, promoting the repopulation of neighboring epithelial cells. And other myriad of factors-classified as damage-associated molecular patterns (DAMPs)-function as "find me" (attractant), "eat me" (engulfment), or "danger" (activation) signals for recruiting and activating effector immune cells (e.g., dendritic cells) to initiate inflammation. Since the discovery of immunogenic cell death (ICD), the current dogma posits DAMPs as immunological adjuvants for innate immune cell mobilization and activation, which ultimately leads to the antitumoral cross-priming of CD8

Indexed as

chemotherapydamage-associate molecular patterngemcitabineimmune-checkpoint blockade therapyimmunogenic cell deathprostaglandin E2

Identifiers

PMID33821233
PMCPMC8012883
OpenAlexW3144957430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.