Evidence map›Paper›PMID 33821222›Full record

ReviewGene reports2021

An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies.

Ankur Das, Raja Ahmed, Suraiya Akhtar, Khaleda Begum, Sofia Banu

Open access · greenAbstract readReview
In one paragraph

Review in Gene reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Polarimetric imaging for the detection of synthetic models of SARS-CoV-2: A proof of concept.Journal of quantitative spectroscopy & radiative transfer · 2023
    Article
  6. Review
  7. Review
  8. All Microbiological Aspects of SARS-CoV-2 Virus.The Eurasian journal of medicine · 2022
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Pea eggplant (PeerJ · 2022
    Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ankur DasDepartment of Bioengineering and Technology, Gauhati University, Guwahati, Assam 781014, India.
Raja AhmedDepartment of Bioengineering and Technology, Gauhati University, Guwahati, Assam 781014, India.
Suraiya AkhtarDepartment of Bioengineering and Technology, Gauhati University, Guwahati, Assam 781014, India.
Khaleda BegumDepartment of Bioengineering and Technology, Gauhati University, Guwahati, Assam 781014, India.
Sofia BanuDepartment of Bioengineering and Technology, Gauhati University, Guwahati, Assam 781014, India.
Gauhati University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus Disease 2019 (COVID-19) manifests as extreme acute respiratory conditions caused by a novel beta coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But, specific furin site in the spike protein, mutation prone and phylogenetically mess open reading frame1ab (Orf1ab) separates SARS-CoV-2 from other RNA viruses. Since the outbreak (February-March 2020), researchers, scientists, and medical professionals are inspecting all possible facts and aspects including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural and expression based functional information of proteins, and utilization of this information in optimizing strategies to prevent its spread. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2.

Indexed as

AEC2, angiotensin-converting enzyme 2CD4 and CD8, cluster of differentiationCDC, Centers for Disease Control and PreventionCOVID-19, Coronavirus Diseases 2019Genome organization and expressionGM-CSF, macrophage colony-stimulating factorHCV, hepatitis C virusHIV, human immune deficiency virusLAMP, loop mediated isothermal amplificationMARS-CoV, Middle East Respiratory Syndrome CoronavirusPrevention strategiesSARS-CoV-2SARS-CoV-2, severe acute respiratory syndrome coronavirus 2WHO, World Health Organization

Identifiers

PMID33821222
PMCPMC8012276
OpenAlexW3149723115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.