Evidence map›Paper›PMID 33821000›Full record

ArticleNature neuroscience2021

A genetically encoded sensor for measuring serotonin dynamics.

Jinxia Wan, Wanling Peng, Xuelin Li, Tongrui Qian, Kun Song, Jianzhi Zeng, Fei Deng, Suyu Hao, Jiesi Feng, Peng Zhang and 9 more

Open access · greenAbstract read
In one paragraph

Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 292 citations in OpenAlex.

  1. A Chemigenetic Fluorescence Lifetime Biosensor for Dopamine Sensing.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. A molecular integrator of sleep duration and interruption.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. A discrete serotonergic circuit involved in the generation of tinnitus behavior.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
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  17. Article
  18. Measuring serotonin binding to its receptorsbioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Jinxia WanState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-5942-1465
Wanling PengInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Xuelin LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Tongrui QianState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-0329-4687
Kun SongInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-6379-2805
Jianzhi ZengState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-5380-6281
Fei DengState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Suyu HaoState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Jiesi FengState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Peng ZhangDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Yajun ZhangDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Jing ZouState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Sunlei PanState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Mimi ShinDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
B Jill VentonDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
J Julius ZhuDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-1879-983X
Miao JingChinese Institute for Brain Research, Beijing, China.
Min XuInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-6936-7543
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China. yulongli@pku.edu.cn.ORCID http://orcid.org/0000-0002-9166-9919
Peking University · CNUniversity of Virginia · USChinese Academy of Sciences · CNChinese Institute for Brain Research · CNMcGovern Institute for Brain Research · USUniversity of Southern California · US

Funding

Novel fluorescent sensors based on GPCRs for imaging neuromodulationU01NS103558 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2017 to 2019
$2.2M
Genetically-encoded ACh sensorsR01NS104670 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2018 to 2022
$2.2M
Calcium channel and glutamate receptor signaling at synapsesR01NS091452 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2015 to 2019
$1.7M
Mechanisms of Synaptic Depression: Focus on Rap Signaling PathwaysR01NS051241 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2006 to 2010
$1.2M
NINDS NIH HHS R01 NS051241NINDS NIH HHS R01 NS091452NINDS NIH HHS R01 NS104670NINDS NIH HHS U01 NS103558
6 · The paper itself

Abstract

Serotonin (5-HT) is a phylogenetically conserved monoamine neurotransmitter modulating important processes in the brain. To directly visualize the release of 5-HT, we developed a genetically encoded G-protein-coupled receptor (GPCR)-activation-based 5-HT (GRAB

Indexed as

AnimalsFemaleHEK293 CellsHumansMaleMiceNeuronsRatsReceptors, G-Protein-CoupledSerotonergic NeuronsSerotoninSignal TransductionReceptors, G-Protein-CoupledSerotonin

Identifiers

PMID33821000
PMCPMC8544647
OpenAlexW3146171909

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.