ArticleNature methods2021
A three-dimensional virtual mouse generates synthetic training data for behavioral analysis.
Article in Nature methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Cheese3D enables sensitive detection and analysis of whole-face movement in mice.Nature neuroscience · 2026Article
- AVATAR: AI Vision Analysis for Three-dimensional Action in Real-time.Experimental neurobiology · 2026Article
- Medial prefrontal cortex activity precedes dorsomedial striatum in need for change during history-based flexible behavior.iScience · 2025Article
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- An integrative assay for measuring social aversion and motivation in freely behaving mice.Cell reports methods · 2025Article
- Telecentric stereo 3D imaging with isotropic micrometer resolution bridges macro- and microscale in small Lepidopterans.Scientific reports · 2025Article
- Article
- Improving the performance of 3D image model compression based on optimized DEFLATE algorithm.Scientific reports · 2024Article
- A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration.Nature communications · 2024Article
- Development of AI-assisted microscopy frameworks through realistic simulation with pySTED.Nature machine intelligence · 2024Article
- Three-dimensional surface motion capture of multiple freely moving pigs using MAMMAL.Nature communications · 2023Article
- replicAnt: a pipeline for generating annotated images of animals in complex environments using Unreal Engine.Nature communications · 2023Article
- Rapid automated 3-D pose estimation of larval zebrafish using a physical model-trained neural network.PLoS computational biology · 2023Article
- Comparative morphology of the whiskers and faces of mice (Mus musculus) and rats (Rattus norvegicus).The Journal of experimental biology · 2023Article
- Large-scale capture of hidden fluorescent labels for training generalizable markerless motion capture models.Nature communications · 2023Article
- Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine.Communications biology · 2023Article
- Improved 3D Markerless Mouse Pose Estimation Using Temporal Semi-Supervision.International journal of computer vision · 2023Article
- Estimation of skeletal kinematics in freely moving rodents.Nature methods · 2022Article
- Towards a Visualizable, De-identified Synthetic Biomarker of Human Movement Disorders.Journal of Parkinson's disease · 2022Article
- The emergence and influence of internal states.Neuron · 2022Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
We developed a three-dimensional (3D) synthetic animated mouse based on computed tomography scans that is actuated using animation and semirandom, joint-constrained movements to generate synthetic behavioral data with ground-truth label locations. Image-domain translation produced realistic synthetic videos used to train two-dimensional (2D) and 3D pose estimation models with accuracy similar to typical manual training datasets. The outputs from the 3D model-based pose estimation yielded better definition of behavioral clusters than 2D videos and may facilitate automated ethological classification.
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