Evidence map›Paper›PMID 33820987›Full record

ArticleNature methods2021

Miniaturized head-mounted microscope for whole-cortex mesoscale imaging in freely behaving mice.

Mathew L Rynes, Daniel A Surinach, Samantha Linn, Michael Laroque, Vijay Rajendran, Judith Dominguez, Orestes Hadjistamoulou, Zahra S Navabi, Leila Ghanbari, Gregory W Johnson and 3 more

Open access · greenAbstract read
In one paragraph

Article in Nature methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 107 citations in OpenAlex.

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  17. Biphasic acclimation for simultaneous wide-field fluorescent CaImaging neuroscience (Cambridge, Mass.) · 2026
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Mathew L Rynes *Department of Biomedical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-6999-6537
Daniel A Surinach *Department of Mechanical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Samantha LinnDepartment of Mechanical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Michael LaroqueSchools of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Vijay RajendranDepartment of Mechanical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Judith DominguezDepartment of Mechanical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Orestes HadjistamoulouDepartment of Mechanical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Zahra S NavabiDepartment of Mechanical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Leila GhanbariDepartment of Mechanical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-0582-6739
Gregory W JohnsonDepartment of Mechanical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Mojtaba NazariDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Majid H MohajeraniDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Suhasa B KodandaramaiahDepartment of Biomedical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN, USA. suhasabk@umn.edu.ORCID http://orcid.org/0000-0002-7767-2644
University of Minnesota · USUniversity of Lethbridge · CAUniversity of Minnesota Medical Center · US

Funding

Miniaturized head-mounted device for pan-cortical electro-optical activity monitoringR01NS111028 · NINDS · UNIVERSITY OF MINNESOTA · PI KODANDARAMAIAH, SUHASA B, SWISHER, SARAH L · 2019 to 2023
$2.4M
Opto-Crown: Transparent skulls with embedded optics for cortex-wide cellular resolution imaging in freely moving miceRF1NS113287 · NINDS · UNIVERSITY OF MINNESOTA · PI BOYDEN, EDWARD S., KODANDARAMAIAH, SUHASA B · 2019 to 2019
$2.0M
Supplement: Robotic Platform for High-Densisty in Vivo Intracellular recordingR21NS103098 · NINDS · UNIVERSITY OF MINNESOTA · PI HARNETT, MARK THOMAS, KODANDARAMAIAH, SUHASA B · 2017 to 2018
$483k
Functional and transcriptomic profiling of synaptically connected dorsal horn neuronsR21NS112886 · NINDS · UNIVERSITY OF MINNESOTA · PI KODANDARAMAIAH, SUHASA B, VULCHANOVA, LYUDMILA H · 2019 to 2020
$411k
Headborne autopatchers for autonomous intracellular recordings in freely moving, behaving ratsR21NS111196 · NINDS · UNIVERSITY OF MINNESOTA · PI KODANDARAMAIAH, SUHASA B · 2019 to 2019
$390k
NINDS NIH HHS R01 NS111028NINDS NIH HHS R21 NS103098NINDS NIH HHS R21 NS111196NINDS NIH HHS R21 NS112886NINDS NIH HHS RF1 NS113287
6 · The paper itself

Abstract

The advent of genetically encoded calcium indicators, along with surgical preparations such as thinned skulls or refractive-index-matched skulls, has enabled mesoscale cortical activity imaging in head-fixed mice. However, neural activity during unrestrained behavior substantially differs from neural activity in head-fixed animals. For whole-cortex imaging in freely behaving mice, we present the 'mini-mScope', a widefield, miniaturized, head-mounted fluorescence microscope that is compatible with transparent polymer skull preparations. With a field of view of 8 × 10 mm

Indexed as

MiniaturizationAnimalsCerebral CortexMiceMicroscopy, Fluorescence

Identifiers

PMID33820987
PMCPMC8034419
OpenAlexW3147351044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.