Evidence map›Paper›PMID 33820958›Full record

Observational studyGenetics in medicine : official journal of the American College of Medical Genetics2021

1-

Irini Manoli, Alexandra R Pass, Elizabeth A Harrington, Jennifer L Sloan, Jack Gagné, Samantha McCoy, Sarah L Bell, Jacob D Hattenbach, Brooks P Leitner, Courtney J Duckworth and 11 more

Erratum issued Registry-linked trialOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Genetics in medicine : official journal of the American College of Medical Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT00078078 (Clinical and Basic Investigations of Methylmalonic Acidemia), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00078078 recruitingnot on this map

Clinical and Basic Investigations of Methylmalonic Acidemia (MMA) and Related Disorders

TypeobservationalSponsorNational Human Genome Research Institute (NHGRI)Ran2004Enrolled2,275ConditionsOrganic Acidemia, Methylmalonic Acidemia, Inborn Errors of Metabolism
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Short-chain fatty acids.Nature metabolism · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Chemoproteomics Yields a Selective Molecular Host for Acetyl-CoA.Journal of the American Chemical Society · 2023
    Article
  9. Review
  10. Effects of ethanol and sex on propionate metabolism evaluatedWorld journal of gastroenterology · 2023
    Article
  11. Evaluation of the One-Hour ¹³C-Propionate Breath Test in 49 Patients from a Single Center in Japan to Detect Vitamin B₁₂ Deficiency.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
  12. Review
  13. Severity modeling of propionic acidemia using clinical and laboratory biomarkers.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 1 country.

Irini ManoliMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Alexandra R PassMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Elizabeth A HarringtonMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Jennifer L SloanMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Jack GagnéMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Samantha McCoyMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Sarah L BellDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Jacob D HattenbachDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Brooks P LeitnerDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Courtney J DuckworthDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Laura A FletcherDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Thomas M CassimatisDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Carolina I GalarretaMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Audrey ThurmPediatrics and Developmental Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Joseph SnowOffice of the Clinical Director, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Carol Van RyzinMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Susan FerryMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Nicholas Ah MewChildren's National Health System, Washington, DC, USA.
Oleg A ShchelochkovMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Kong Y ChenDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Charles P VendittiMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. venditti@mail.nih.gov.ORCID 0000-0001-6599-1253
National Institutes of Health · USNational Human Genome Research Institute · USNational Institute of Diabetes and Digestive and Kidney Diseases · USChildren's National · USNational Institute of Mental Health · US

Funding

Investigations of Methylmalonic Acidemia and Related DisordersZIAHG200318 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI VENDITTI, CHARLES P · 2009 to 2025
$29.7M
Metabolic Research Core: energy balance and obesity studiesZICDK071013 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CHEN, KONG · 2009 to 2025
$12.3M
Intramural NIH HHS ZIA HG200318
6 · The paper itself

Abstract

purposeTo develop a safe and noninvasive in vivo assay of hepatic propionate oxidative capacity.

methodsA modified 1-

resultsLower propionate oxidation was observed in patients with the severe mut

conclusionPropionate oxidative capacity, as measured with 1-

trial registrationThis clinical study is registered in www.clinicaltrials.gov with the ID: NCT00078078. Study URL: http://clinicaltrials.gov/ct2/show/NCT00078078.

Indexed as

Amino Acid Metabolism, Inborn ErrorsPropionatesBiomarkersBreath TestsHumansLiverMethylmalonic AcidBiomarkersMethylmalonic AcidPropionates

Identifiers

PMID33820958
PMCPMC8354855
OpenAlexW4210983423

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.