ArticleScientific reports2021
Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Optical coherence tomography enables optical biopsy of endometrial tissue for early cancer detection.Npj imaging · 2026Article
- OCT in Oncology and Precision Medicine: From Nanoparticles to Advanced Technologies and AI.Bioengineering (Basel, Switzerland) · 2025Review
- In situ expansion capacity evaluation of terminal alveoli in chronic obstructive pulmonary disease using an ultrathin optical coherence tomography catheter.Biomedical optics express · 2025Article
- HPV integration profiling using nanopore sequencing and association with cervical precancerous lesion.Frontiers in microbiology · 2025Article
- A Deep Learning Model for Cervical Optical Coherence Tomography Image Classification.Diagnostics (Basel, Switzerland) · 2024Article
- Awareness of HPV and HPV vaccine among college students in China.Frontiers in public health · 2024Article
- Study on the application of optical coherence microscopy in Hirschsprung's disease.Scientific reports · 2023Article
- Efficacy of optical coherence tomography in the triage of women with minor abnormal cervical cytology before colposcopy.PloS one · 2023Article
- Development of a multimodal mobile colposcope for real-time cervical cancer detection.Biomedical optics express · 2022Article
- A unique Levey-Jennings control chart used for internal quality control in human papillomavirus detection.Virology journal · 2022Article
- Study on the application and imaging characteristics of optical coherence tomography in vulva lesions.Scientific reports · 2022Article
- Research progress on the application of optical coherence tomography in the field of oncology.Frontiers in oncology · 2022Review
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were clearly observed in OCT images, which matched well with the corresponding histological sections. The OCT diagnosis results delivered a sensitivity of 87.0% (95% confidence interval, CI 82.2-90.7%), a specificity of 84.1% (95% CI 80.3-87.2%), and an overall accuracy of 85.1%. Both good consistency of OCT images and histological images and satisfactory diagnosis results were provided by OCT. Due to its features of non-invasion, real-time, and accuracy, OCT is valuable for the in-vivo evaluation of cervical lesions and has the potential to be one of the routine cervical diagnosis methods.
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