Evidence map›Paper›PMID 33820824›Full record

ArticlemBio2021

Genome-Wide Analysis of Experimentally Evolved Candida auris Reveals Multiple Novel Mechanisms of Multidrug Resistance.

Hans Carolus, Siebe Pierson, José F Muñoz, Ana Subotić, Rita B Cruz, Christina A Cuomo, Patrick Van Dijck

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 3 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 3 syntheses or guidelines pooled it, 188 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Global characteristics and trends in research onFrontiers in microbiology · 2023
    Pooled it
  4. Article
  5. Pharmacological advances inJournal of enzyme inhibition and medicinal chemistry · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Active Screening forJournal of fungi (Basel, Switzerland) · 2026
    Review
  10. Article
  11. Micafungin exposure drives multidrug resistance inbioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Article
  14. Isolation of a multidrug-resistantMedical mycology case reports · 2026
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Deciphering the multidrug resistance paradigm inAntimicrobial agents and chemotherapy · 2026
    Review

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hans CarolusVIB Center for Microbiology, Leuven, Belgium.ORCID 0000-0003-1507-3475
Siebe PiersonDepartment of Biology, KU Leuven, Leuven, Belgium.ORCID 0000-0002-4315-7943
José F MuñozBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.ORCID 0000-0003-4987-7957
Ana SubotićVIB Center for Microbiology, Leuven, Belgium.ORCID 0000-0002-0713-455X
Rita B CruzDepartment of Biology, KU Leuven, Leuven, Belgium.
Christina A CuomoBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.ORCID 0000-0002-5778-960X
Patrick Van DijckVIB Center for Microbiology, Leuven, Belgium patrick.vandijck@kuleuven.be.ORCID 0000-0002-1542-897X
VIB-KU Leuven Center for Microbiology · BEBroad Institute · USKU Leuven · BE

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI SABETI, PARDIS CHRISTINE · 2014 to 2024
$66.5M
NIAID NIH HHS U19 AI110818
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genome, FungalMutationAntifungal AgentsCandidaCandidiasisDirected Molecular EvolutionDrug Resistance, Multiple, FungalFungal ProteinsHumansMicrobial Sensitivity TestsAntifungal AgentsFungal Proteinsamphotericin Bantifungal agentsCandida auriscaspofungindrug resistance evolutionexperimental evolutionfluconazolegenome analysismicroevolutionmultidrug resistancewhole-genome sequencing

Identifiers

PMID33820824
PMCPMC8092288
OpenAlexW3145703097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.