Evidence map›Paper›PMID 33820819›Full record

ArticleInfection and immunity2021

The RD2 Pathogenicity Island Modifies the Disease Potential of the Group A

Roshika Roshika, Ira Jain, Josette Medicielo, Jasmin Wächter, Jessica L Danger, Paul Sumby

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. The dynamic Alp landscape ofFrontiers in cellular and infection microbiology · 2026
    Article
  2. Article
  3. The group AInfection and immunity · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Roshika RoshikaDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Ira JainDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Josette MedicieloDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Jasmin WächterDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Jessica L DangerDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Paul SumbyDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
University of Nevada, Reno · US

Funding

IMMUNOMODULATORY FUNCTIONS OF THE NF-KB/IKB FAMILYZ01AI000722 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI SIEBENLIST, ULRICH · 1995 to 2008
$3.3M
The variable disease potential of group A Streptococcus isolates: a link to puerperal infectionsR21AI148813 · NIAID · UNIVERSITY OF NEVADA RENO · PI SUMBY, PAUL · 2020 to 2021
$393k
Puerperal sepsis and group A Streptococcus heterogeneityR03AI128290 · NIAID · UNIVERSITY OF NEVADA RENO · PI SUMBY, PAUL · 2017 to 2018
$144k
Intramural NIH HHS Z01 AI000722NIAID NIH HHS R03 AI128290NIAID NIH HHS R21 AI148813
6 · The paper itself

Abstract

Serotype M28 isolates of the group A

Indexed as

DNA Transposable ElementsGenomic IslandsCell LineGain of Function MutationHumansPhenotypeSepsisSerogroupStreptococcal InfectionsStreptococcus pyogenesDNA Transposable Elementsmobile genetic elementsStreptococcus pyogenesvirulence

Identifiers

PMID33820819
PMCPMC8281230
OpenAlexW3146388753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.