Evidence map›Paper›PMID 33820818›Full record

ArticleInfection and immunity2021

Leishmania donovani Targets Host Transcription Factor NRF2 To Activate Antioxidant Enzyme HO-1 and Transcriptional Repressor ATF3 for Establishing Infection.

Shriya Saha, Shalini Roy, Ananya Dutta, Kuladip Jana, Anindita Ukil

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Adenosine/AmBio · 2026
    Article
  8. Article
  9. Oxidative Stress and Survival ofExpert reviews in molecular medicine · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. IFN-λ3 is induced byInfection and immunity · 2024
    Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Shriya SahaDepartment of Biochemistry, University of Calcutta, Kolkata, India.
Shalini RoyInfectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Ananya DuttaDivision of Molecular Medicine, Bose Institute, P1/12 Calcutta Improvement Trust Scheme VIIM, Kolkata, India.
Kuladip JanaDivision of Molecular Medicine, Bose Institute, P1/12 Calcutta Improvement Trust Scheme VIIM, Kolkata, India.
Anindita UkilDepartment of Biochemistry, University of Calcutta, Kolkata, India.
Bose Institute · INUniversity of Calcutta · INIndian Institute of Chemical Biology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We showed previously that antioxidant enzyme heme oxygenase 1 (HO-1) is critical for

Indexed as

Host-Pathogen InteractionsActivating Transcription Factor 3AnimalsCytokinesHeme Oxygenase-1Inflammation MediatorsLeishmania donovaniLeishmaniasis, VisceralMacrophagesMiceNF-E2-Related Factor 2Reactive Oxygen SpeciesActivating Transcription Factor 3CytokinesHeme Oxygenase-1Inflammation MediatorsNF-E2-Related Factor 2Reactive Oxygen SpeciesATF3HO-1LeishmaniamacrophagemacrophagesNRF2

Identifiers

PMID33820818
PMCPMC8373246
OpenAlexW3152265807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.