Evidence map›Paper›PMID 33820802›Full record

ArticleeNeuro

Theta Oscillations Gate the Transmission of Reliable Sequences in the Medial Entorhinal Cortex.

Arun Neru, Collins Assisi

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Arun NeruDivision of Biology, Indian Institute of Science Education and Research, Pune 411008, India arun.neru@students.iiserpune.ac.in collins@iiserpune.ac.in.
Collins AssisiDivision of Biology, Indian Institute of Science Education and Research, Pune 411008, India arun.neru@students.iiserpune.ac.in collins@iiserpune.ac.in.
Indian Institute of Science Education and Research Pune · IN

Funding

DBT-Wellcome Trust India Alliance IA/I/11/2500290
6 · The paper itself

Abstract

Stability and precision of sequential activity in the entorhinal cortex (EC) is crucial for encoding spatially guided behavior and memory. These sequences are driven by constantly evolving sensory inputs and persist despite a noisy background. In a realistic computational model of a medial EC (MEC) microcircuit, we show that intrinsic neuronal properties and network mechanisms interact with theta oscillations to generate reliable outputs. In our model, sensory inputs activate interneurons near their most excitable phase during each theta cycle. As the inputs change, different interneurons are recruited and postsynaptic stellate cells are released from inhibition. This causes a sequence of rebound spikes. The rebound time scale of stellate cells, because of an

Indexed as

Entorhinal CortexModels, NeurologicalAction PotentialsInterneuronsNeuronsTheta Rhythmentorhinalgatinggrid cellssequencestabilitytheta

Identifiers

PMID33820802
PMCPMC8208650
OpenAlexW3146847267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.