Evidence map›Paper›PMID 33820762›Full record

ArticleAntimicrobial agents and chemotherapy2021

Role of Synonymous Mutations in the Evolution of TEM β-Lactamase Genes.

Mohammad Faheem, Charles J Zhang, Monica N Morris, Juergen Pleiss, Peter Oelschlaeger

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Impact of synonymous mutations in theMicrobiology spectrum · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Mohammad FaheemDepartment of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.
Charles J ZhangDepartment of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.ORCID 0000-0003-0300-849X
Monica N MorrisDepartment of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.ORCID 0000-0002-9815-0810
Juergen PleissInstitute of Biochemistry and Technical Biochemistry, University of Stuttgart, Stuttgart, Germany.ORCID 0000-0003-1045-8202
Peter OelschlaegerDepartment of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA poelschlaeger@westernu.edu.ORCID 0000-0001-5949-9297
Western University of Health Sciences · USUniversity of Stuttgart · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonsynonymous mutations are well documented in TEM β-lactamases. The resulting amino acid changes often alter the conferred phenotype from broad spectrum (2b) conferred by TEM-1 to extended spectrum (2be), inhibitor resistant (2br), or both extended spectrum and inhibitor resistant (2ber). The encoding

Indexed as

beta-LactamasesEscherichia coli InfectionsEscherichia coliHumansMicrobial Sensitivity TestsSilent Mutationbeta-LactamasesevolutionmRNA secondary structuresynonymous mutationβ-lactamase

Identifiers

PMID33820762
PMCPMC8315918
OpenAlexW3143421708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.