ReviewEpidemiology and psychiatric sciences2021
Neuroimaging studies exploring the neural basis of social isolation.
Review in Epidemiology and psychiatric sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06138301 (Digital Interventions for Social isOLation In youThs And theIR familiEs), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Digital Interventions for Social isOLation In youThs And theIR familiEs
Who cites it
21 citing papers in PubMed.
- Social Working Memory: a Systematic Review.Neuropsychology review · 2026Review
- Brain activity and functional connectivity patterns associated with loneliness: A resting-state fMRI study.Cognitive, affective & behavioral neuroscience · 2026Article
- Association between loneliness and hippocampal responses to dynamic social stimuli in psychotic disorders.Psychological medicine · 2025Article
- Loneliness in schizophrenia: Just loneliness.Annals of the New York Academy of Sciences · 2025Review
- Individual differences in experiential diversity shape event segmentation granularity.iScience · 2025Article
- Investigating the Overlap ofMedicina (Kaunas, Lithuania) · 2025Article
- Activity participation on executive functions and well- being of hearing impaired children.BMC public health · 2025Article
- Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality.Nature human behaviour · 2025Article
- Critical Review of Neurobiological Evidence for Relationships Between Social Isolation, Loneliness and the Risk of Developing of Alzheimer's Disease: A New Model.Journal of aging research · 2025Review
- Topic: Evaluation and Treatment of Social Isolation and Loneliness: Evidence-based Recommendations for Stroke and Neurological Rehabilitation.Current physical medicine and rehabilitation reports · 2025Article
- Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats.Neurochemical research · 2024Article
- Salience Network Functional Connectivity Mediates Association Between Social Engagement and Cognition in Non-Demented Older Adults: Exploratory Investigation.Journal of Alzheimer's disease reports · 2024Article
- Impaired social concept processing in persons with autistic-like traits.Scientific reports · 2023Article
- Social Withdrawal, Loneliness, and Health in Schizophrenia: Psychological and Neural Mechanisms.Schizophrenia bulletin · 2023Article
- The VLPFC-Engaged Voluntary Emotion Regulation: Combined TMS-fMRI Evidence for the Neural Circuit of Cognitive Reappraisal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Abnormal Brain Structure Is Associated with Social and Communication Deficits in Children with Autism Spectrum Disorder: A Voxel-Based Morphometry Analysis.Brain sciences · 2023Article
- Changes in fear-associated learning task brain activation over the COVID-19 pandemic period: a preliminary longitudinal analysis.Frontiers in psychiatry · 2023Article
- Waist-to-calf circumstance ratio and cognitive function among Chinese older adults: Mediating roles of physical performance and social activity.Frontiers in aging neuroscience · 2023Article
- The impact of hearing loss on cognitive impairment: The mediating role of depressive symptoms and the moderating role of social relationships.Frontiers in public health · 2023Article
- Hikikomori: A Society-Bound Syndrome of Severe Social Withdrawal.Psychiatry and clinical psychopharmacology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the social brain hypothesis, the human brain includes a network designed for the processing of social information. This network includes several brain regions that elaborate social cues, interactions and contexts, i.e. prefrontal paracingulate and parietal cortices, amygdala, temporal lobes and the posterior superior temporal sulcus. While current literature suggests the importance of this network from both a psychological and evolutionary perspective, little is known about its neurobiological bases. Specifically, only a paucity of studies explored the neural underpinnings of constructs that are ascribed to the social brain network functioning, i.e. objective social isolation and perceived loneliness. As such, this review aimed to overview neuroimaging studies that investigated social isolation in healthy subjects. Social isolation correlated with both structural and functional alterations within the social brain network and in other regions that seem to support mentalising and social processes (i.e. hippocampus, insula, ventral striatum and cerebellum). However, results are mixed possibly due to the heterogeneity of methods and study design. Future neuroimaging studies with longitudinal designs are needed to measure the effect of social isolation in experimental v. control groups and to explore its relationship with perceived loneliness, ultimately helping to clarify the neural correlates of the social brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.