Evidence map›Paper›PMID 33820540›Full record

ArticleBMC cardiovascular disorders2021

Total cholesterol/HDL-C ratio versus non-HDL-C as predictors for ischemic heart disease: a 17-year follow-up study of women in southern Sweden.

Susanna Calling, Sven-Erik Johansson, Moa Wolff, Jan Sundquist, Kristina Sundquist

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Susanna CallingCenter for Primary Health Care Research, Clinical Research Centre, Department of Clinical Sciences in Malmö, Lund University, Box 50332, 202 13, Malmö, Region Skåne, Sweden. susanna.calling@med.lu.se.
Sven-Erik JohanssonCenter for Primary Health Care Research, Clinical Research Centre, Department of Clinical Sciences in Malmö, Lund University, Box 50332, 202 13, Malmö, Region Skåne, Sweden.
Moa WolffCenter for Primary Health Care Research, Clinical Research Centre, Department of Clinical Sciences in Malmö, Lund University, Box 50332, 202 13, Malmö, Region Skåne, Sweden.
Jan SundquistCenter for Primary Health Care Research, Clinical Research Centre, Department of Clinical Sciences in Malmö, Lund University, Box 50332, 202 13, Malmö, Region Skåne, Sweden.
Kristina SundquistCenter for Primary Health Care Research, Clinical Research Centre, Department of Clinical Sciences in Malmö, Lund University, Box 50332, 202 13, Malmö, Region Skåne, Sweden.
Lund University · SEMalmö University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA distorted blood lipid profile is an important risk factor for ischemic heart disease (IHD) but the predictive ability of the different lipid measures has rarely been studied. Our aim was to examine and compare, in a large sample of women, the predictive ability of total cholesterol/HDL cholesterol ratio (TC/HDL-C) and non-HDL-C in relation to IHD, adjusted for age, exercise, smoking, waist-hip ratio, blood pressure, and diabetes mellitus.

methodsBetween 1995 and 2000, a total of 6537 women aged 50-59 years from the Women's Health in Lund area (WHILA) study in southern Sweden were included and underwent a baseline examination. The women were followed through national registers for incidence of IHD during a mean follow-up of 17 years. The prediction accuracy was estimated through Harrell's C and Akaike Information Criterion (AIC).

resultsIncreasing TC/HDL-C as well as non-HDL-C showed strong associations with IHD, with the highest risk in the 5th quintile, where the HR was 2.30 (95% CI: 1.70-3.11) for TC/HDL-C and 1.67 (95% CI: 1.25-2.24) for non-HDL-C, after adjustments. Comparisons using Harrell's C and AIC indicated that TC/HDL-C has a slightly higher predictive ability than that of non-HDL-C (Harrell's C 0.62 and 0.59 respectively, p = 0.003 for difference, age-adjusted model; AIC for TC/HDL-C < AIC for non-HDL-C).

conclusionsTC/HDL-C ratio and non-HDL-C are both clinical predictors for IHD in middle-aged women. The results indicate that the predictive ability of TC/HDL-C was higher than that of non-HDL-C; however, non-HDL-C was linearly related to IHD (p = 0.58) and may be easier to calculate and interpret in clinical practice, for early identification of future IHD in women.

Indexed as

BiomarkersCholesterolCholesterol, HDLDyslipidemiasFemaleFollow-Up StudiesHeart Disease Risk FactorsHumansIncidenceMiddle AgedMyocardial IschemiaRisk AssessmentSwedenTime FactorsBiomarkersCholesterolCholesterol, HDLCholesterolHyperlipidemiasIschemic heart diseaseLipoproteinsNon-HDL cholesterolWomen

Identifiers

PMID33820540
PMCPMC8020530
OpenAlexW3144175659

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.