Evidence map›Paper›PMID 33820469›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2021

Cancer and stem cells.

Wen Yin, Jialing Wang, Linling Jiang, Y James Kang

Open access · greenAbstract readReview
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.

  1. Pooled it
  2. Body compassion as a mediator between demoralization, fear of cancer recurrence, and body image concerns in women with breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
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  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. New Phenylpropanoid fromCurrent pharmaceutical design · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Diallyl disulfide in oncotherapy: molecular mechanisms and therapeutic potentials.Apoptosis : an international journal on programmed cell death · 2025
    Review
  15. Review
  16. The sole use of stem cells in treating fracture nonunion: a scoping review.Archives of orthopaedic and trauma surgery · 2025
    Article
  17. Review
  18. In Vitro Anti-Glioblastoma Activity ofLife (Basel, Switzerland) · 2025
    Article
  19. Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Wen YinRegenerative Medicine Research Center, Sichuan University West China Hospital, Sichuan 610041, China.
Jialing WangRegenerative Medicine Research Center, Sichuan University West China Hospital, Sichuan 610041, China.
Linling JiangRegenerative Medicine Research Center, Sichuan University West China Hospital, Sichuan 610041, China.
Y James KangRegenerative Medicine Research Center, Sichuan University West China Hospital, Sichuan 610041, China.ORCID 0000-0001-8449-7904
Sichuan University · CNUniversity of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Being the second leading cause of death globally, cancer has been a long-standing and rapidly evolving focus of biomedical research and practice in the world. A tremendous effort has been made to understand the origin of cancer cells, the formation of cancerous tissues, and the mechanism by which they spread and relapse, but the disease still remains mysterious. Here, we made an attempt to scrutinize evidences that indicate the role of stem cells in tumorigenesis and metastasis, and cancer relapse. We also looked into the influence of cancers on stem cells, which in turn represent a major constituent of tumor microenvironment. Based on current understandings of the properties of (cancer) stem cells and their relation to cancers, we can foresee that novel therapeutic approaches would become the next wave of cancer treatment.

Indexed as

Tumor MicroenvironmentCarcinogenesisCell- and Tissue-Based TherapyCell Transformation, NeoplasticHumansNeoplasm Recurrence, LocalNeoplastic Stem CellsCancercancer stem cellsmetastasisstem cellstumorigenesistumor microenvironment

Identifiers

PMID33820469
PMCPMC8381702
OpenAlexW3146914055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.