ReviewThe Journal of international medical research2021
Two cases of special POEMS syndrome without monoclonal protein expression: a case report and literature review.
Review in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Atypical Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, and Skin Changes (POEMS) Syndrome.Cureus · 2026Article
- [Clinical characteristics of POEMS syndrome initially diagnosed as increased extravascular volume load: a single-center retrospective study].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Article
- [POEMS syndrome. Report of three cases and literature review].Revista medica del Instituto Mexicano del Seguro Social · 2024Review
- Detection of clonal plasma cells in POEMS syndrome using multiparameter flow cytometry.Scientific reports · 2024Article
- Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.Frontiers in medicine · 2024Article
- A rare case of POEMS syndrome presenting as essential thrombocythemia.Oxford medical case reports · 2022Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes) syndrome is rare, with polyneuropathy and monoclonal plasma cell disorder generally considered as essential diagnostic symptoms. We report two cases of POEMS syndrome without monoclonal protein expression. The first case was a 72-year-old man who had experienced recurrent edema of the lower limbs for 2 years and abdominal distention for 2 months. The other case was a 62-year-old man with a 5-year history of recurrent numbness of the extremities and muscle weakness, which had become serious over the preceding 3 months. Both patients had various symptoms that matched those of POEMS syndrome, but neither had monoclonal protein expression. However, a diagnosis of POEMS syndrome was made in each case. Both patients were treated with lenalidomide and dexamethasone, after which their symptoms improved and laboratory test results normalized. The findings in these two cases suggest the possibility that POEMS syndrome may occur without monoclonal protein expression. The diagnostic criteria of POEMS syndrome may thus need further investigation.
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