Evidence map›Paper›PMID 33820434›Full record

ArticleEpigenomics2021

Methylation quantitative trait locus analysis of chronic postsurgical pain uncovers epigenetic mediators of genetic risk.

Vidya Chidambaran, Xue Zhang, Valentina Pilipenko, Xiaoting Chen, Benjamin Wronowski, Kristie Geisler, Lisa J Martin, Artem Barski, Matthew T Weirauch, Hong Ji

Open access · greenAbstract read
In one paragraph

Article in Epigenomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Vidya ChidambaranDepartment of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0001-7913-1932
Xue ZhangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Valentina PilipenkoDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Xiaoting ChenDivision of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Benjamin WronowskiDivision of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Kristie GeislerDepartment of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Lisa J MartinDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Artem BarskiDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Matthew T WeirauchDivision of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Hong JiDepartment of Anatomy, Physiology & Cell biology, California National Primate Research Center, University of California, Davis, CA 95616, USA.
Cincinnati Children's Hospital Medical Center · USUniversity of California, Davis · US

Funding

UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Nicholas J. KENYON · 2015 to 2026
$26.0M
Epigenetic Determinants Influencing Development and Evolution of Chronic Post-surgical Pain in Children Undergoing Musculoskeletal Surgery.R01AR075857 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI CHIDAMBARAN, VIDYA · 2019 to 2023
$3.0M
Role of TET1 in airway epithelium and childhood asthmaR01AI141569 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JI, HONG · 2019 to 2023
$3.0M
Morphine Pharmacogenomics to Predict Risk of Respiratory Depression in ChildrenK23HD082782 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI CHIDAMBARAN, VIDYA · 2014 to 2018
$655k
NIAID NIH HHS R01 AI141569NIAMS NIH HHS R01 AR075857NICHD NIH HHS K23 HD082782NIEHS NIH HHS P30 ES023513
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Epigenesis, GeneticQuantitative Trait LociChildChronic DiseaseHumansPostoperative ComplicationsPostoperative PainCPSPDNA methylationepigeneticsgeneticsmechanismsmeQTLmethylation quantitative traitPARK16postoperative pain

Identifiers

PMID33820434
PMCPMC8173520
OpenAlexW3142099788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.