ArticleAnnals of pediatric endocrinology & metabolism2021
Role of obesity-induced inflammation in the development of insulin resistance and type 2 diabetes: history of the research and remaining questions.
Article in Annals of pediatric endocrinology & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Anti-Inflammatory, Anti-Obesity, and Insulin-Sensitizing Effects ofFoods (Basel, Switzerland) · 2026Article
- TREM2: A Potential Target for the Targeted Therapy of Metabolic Diseases.Mediators of inflammation · 2026Review
- Effects of canagliflozin combined with metformin therapy on insulin sensitivity in patients with type 2 diabetes mellitus.European journal of medical research · 2025Article
- Diabetes Mellitus and Cardiovascular Disease: Exploring Epidemiology, Pathophysiology, and Treatment Strategies.Reviews in cardiovascular medicine · 2024Review
- Ramadan Intermittent Fasting and Plasma Volume Variations in Individuals with Different Body Weights.Medicina (Kaunas, Lithuania) · 2024Article
- Commentary on "Effects of once-weekly dulaglutide on juvenile type 2 diabetes mellitus and obesity in Korea: a pilot study".Annals of pediatric endocrinology & metabolism · 2023Article
- Nonalcoholic fatty liver disease and insulin resistance in children.Clinical and experimental pediatrics · 2023Article
- Usefulness of glycated albumin level as a glycemic index complementing glycosylated hemoglobin in diabetic children and adolescents.Annals of pediatric endocrinology & metabolism · 2023Article
- Trends in HOMA-IR values among South Korean adolescents from 2007-2010 to 2019-2020: a sex-, age-, and weight status-specific analysis.International journal of obesity (2005) · 2023Article
- Antioxidant, anti-inflammatory, and anticancer function ofFood science & nutrition · 2023Article
- Transcriptomic Analysis from Normal Glucose Tolerance to T2D of Obese Individuals Using Bioinformatic Tools.International journal of molecular sciences · 2023Article
- Multiple Roles of Sirtuin 6 in Adipose Tissue Inflammation.Diabetes & metabolism journal · 2023Review
- Combined Approach: FFQ, DII, Anthropometric, Biochemical and DNA Damage Parameters in Obese with BMI ≥ 35 kg mNutrients · 2023Article
- Inflammatory Cytokine Interleukin-6 (IL-6) Promotes the Proangiogenic Ability of Adipose Stem Cells from Obese SubjectsCurrent stem cell research & therapy · 2023Article
- Change of obesity prevalence and lifestyle patterns before and during COVID-19 among Korean adolescents.Annals of pediatric endocrinology & metabolism · 2022Article
- Commentary on "Single point insulin sensitivity estimator for predicting type 2 diabetes mellitus in obese adolescents".Annals of pediatric endocrinology & metabolism · 2022Article
- Single Point Insulin Sensitivity Estimator for predicting type 2 diabetes mellitus in obese adolescents.Annals of pediatric endocrinology & metabolism · 2022Article
- Implications of Resveratrol in Obesity and Insulin Resistance: A State-of-the-Art Review.Nutrients · 2022Review
- Effects of Inflammatory Factor Expression Regulated by 12/15 Lipoxygenase on Obesity-Related Nephropathy.Nutrients · 2022Article
- Positive Associations between Body Mass Index and Hematological Parameters, Including RBCs, WBCs, and Platelet Counts, in Korean Children and Adolescents.Children (Basel, Switzerland) · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The prevalence of obesity has increased alarmingly both worldwide and in Korea. This has also dramatically increased the prevalence of chronic obesity-associated diseases, including type 2 diabetes (T2D). Extensive studies on the molecular etiology of T2D have revealed several potential mechanisms by which obesity induces the development of insulin resistance and T2D. One of these is low-grade chronic inflammation. Studies hinting at the existence of this phenomenon were first published about 30 years ago. Ten years later, several seminal papers confirmed its existence, which then led to a rapid and massive escalation of research in this field. Today, the notion that obesity-induced inflammation mediates T2D is now well-accepted. This paper will review the key developments in this field, including the discovery that obesity-induced inflammation and insulin resistance is mainly regulated by adipose tissue-resident immune cells, particularly those in visceral adipose tissue. This review further details the research areas, including (1) the obesity-related factors that induce adipose tissue macrophage (ATM) inflammation, (2) the precise effector functions by which adipose tissue immune cells promote insulin resistance, (3) whether there are early immunological events that have an outsize effect on later events and could be targeted to arrest the development of insulin resistance, (4) the roles played by nonimmunological functions of ATMs and other immune cells, and (5) whether there are noncanonical immune responses to obesity (i.e., immune responses that are unique to obesity and cannot be detected by following the discoveries in the classical immunity field).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.