Evidence map›Paper›PMID 33819900›Full record

ArticleParkinsonism & related disorders2021

Thalamic volume mediates associations between cardiorespiratory fitness (VO

Andrew J Petkus, Behnaz Jarrahi, Daniel P Holschneider, Megan E Gomez, J Vincent Filoteo, Dawn M Schiehser, Beth E Fisher, John D Van Horn, Michael W Jakowec, Sarah C McEwen and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
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  4. Greater physical fitness (Acta physiologica (Oxford, England) · 2024
    Article
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Andrew J PetkusDepartment of Neurology, University of Southern California, 1520 San Pablo St., HCC-2, Suite 3000, Los Angeles, CA, 90033, USA. Electronic address: Petkus@usc.edu.
Behnaz JarrahiDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, 94305, USA.
Daniel P HolschneiderDepartment of Neurology, University of Southern California, 1520 San Pablo St., HCC-2, Suite 3000, Los Angeles, CA, 90033, USA; Department of Psychiatry and the Behavioral Sciences, University of Southern California, 1333 San Pablo St., Los Angeles, CA, 90033, USA.
Megan E GomezDepartment of Psychology, Tibor Rubin Veterans Administration Medical Center, Long Beach, CA, 90822, USA.
J Vincent FiloteoPsychology and Research Services, Veterans Administration San Diego Health Care System, San Diego, CA, 92161, USA; Departments of Psychiatry and Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.
Dawn M SchiehserPsychology and Research Services, Veterans Administration San Diego Health Care System, San Diego, CA, 92161, USA; Departments of Psychiatry and Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.
Beth E FisherDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, 90033, USA.
John D Van HornDepartment of Psychology and School of Data Science, University of Virginia, Charlottesville, VA, 22904, USA.
Michael W JakowecDepartment of Neurology, University of Southern California, 1520 San Pablo St., HCC-2, Suite 3000, Los Angeles, CA, 90033, USA.
Sarah C McEwenDepartment of Translational Neurosciences and Neurotherapeutics, Saint John's Cancer Institute, Santa Monica, CA, 90404, USA.
Giselle PetzingerDepartment of Neurology, University of Southern California, 1520 San Pablo St., HCC-2, Suite 3000, Los Angeles, CA, 90033, USA.
University of Southern California · USUC San Diego Health System · USSaint John's Health Center · USStanford University · USTibor Rubin VA Medical Center · USUniversity of Virginia · US

Funding

Multivariate Machine Learning to Characterize Opioid-induced Alterations in the Brain in Chronic PainK25DA048179 · NIDA · STANFORD UNIVERSITY · PI JARRAHI, BEHNAZ · 2020 to 2024
$879k
Biological Mechanisms of Enhanced Neuroplasticity in First-Episode SchizophreniaK01MH099431 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCEWEN, SARAH CHRISTINE · 2012 to 2016
$829k
Cognitive Rehabilitation for Individuals with Parkinson's Disease and MCII01RX001691 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI SCHIEHSER, DAWN M. · 2016 to 2019
–
NIDA NIH HHS K25 DA048179NIMH NIH HHS K01 MH099431RRD VA I01 RX001691
6 · The paper itself

Abstract

introductionCognitive deficits occur in Parkinson's disease (PD). Cardiorespiratory fitness (CRF) is associated with better cognitive performance in aging especially in executive function (EF) and memory. The association between CRF and cognitive performance is understudied in people with PD. Brain structures underlying associations also remains unknown. This cross-sectional study examined the associations between CRF and cognitive performance in PD. We also examined associations between CRF and brain structures impacted in PD. Mediation analysis were conducted to examine whether brain structures impacted in PD mediate putative associations between CRF and cognitive performance.

methodsIndividuals with PD (N = 33) underwent magnetic resonance imaging (MRI), CRF evaluation (estimated VO

resultsHigher CRF was associated with better episodic memory (Standardized β = 0.391; p = 0.008), EF (Standardized β = 0.324; p = 0.025), and visuospatial performance (Standardized β = 0.570; p = 0.005). Higher CRF was associated with larger thalamic (Standardized β = 0.722; p = 0.004) and pallidum (Standardized β = 0.635; p = 0.004) volumes. Thalamic volume mediated the association between higher CRF and better EF (Indirect effect = 0.309) and episodic memory (Indirect effect = 0.209) performance (p < 0.05). The pallidum did not significantly mediate associations between CRF and cognitive outcomes.

conclusionThe thalamus plays an important role in the association between CRF and both EF and episodic memory in PD.

Indexed as

AgedCardiorespiratory FitnessCognitionCognitive DysfunctionCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseaseThalamusCardiorespiratory fitnessCognitionExerciseImagingMRIStructural magnetic resonance imagingThalamus

Identifiers

PMID33819900
PMCPMC8375572
OpenAlexW3152146867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.