ArticleJournal of psychiatric research2021
Is neuroticism differentially associated with risk of Alzheimer's disease, vascular dementia, and frontotemporal dementia?
Article in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Personality and mortality risk: A systematic review and meta-analysis of longitudinal data.Journal of personality and social psychology · 2026Pooled it
- Personality traits and mediating pathways to mortality risk: A systematic review.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Pooled it
- Neuroticism facets and mortality risk in adulthood: A systematic review and narrative synthesis.Journal of psychosomatic research · 2023Pooled it
- Personality trait associations with quality-of-life outcomes following bariatric surgery: a systematic review.Health and quality of life outcomes · 2023Pooled it
- Neuroticism is linked to cognitive decline and increased risk of Alzheimer's disease through dysregulation of excitatory neurons.bioRxiv : the preprint server for biology · 2026Article
- Clinical, cognitive and neuropsychiatric correlates of personality in Wilson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.Alzheimer's research & therapy · 2026Article
- Association between neuroticism and brain-wide structural outcomes: Mediation by vascular and mental conditions.Psychological medicine · 2025Article
- Association of neuroticism with incident dementia and cognitive function: 26-year follow-up of EPIC-Norfolk study.Age and ageing · 2025Article
- Cortical thickness and low-grade inflammation moderate the association between depressive symptoms and cognitive function in early widowhood: A preliminary study.Brain, behavior, and immunity · 2025Article
- Neuroticism is associated with future disease and mortality risks.Chinese medical journal · 2025Article
- Prevalence and pattern of cognitive dysfunction in young adults and middle-aged patients with type-2 diabetes.Journal of family medicine and primary care · 2025Article
- Review
- Mechanical Properties of the Cortex in Older Adults and Relationships With Personality Traits.Human brain mapping · 2025Article
- Frailty links the heterogeneity of tinnitus disorder and response to interventions in older patients.Frontiers in neurology · 2025Review
- Neuroticism, loneliness, all-cause and cause-specific mortality: A 17-year study of nearly 500,000 individuals.Journal of affective disorders · 2025Article
- Biological aging analysis based on DNA methylation status for social anxiety disorder.Neuropsychopharmacology reports · 2024Article
- Examining the Role of Neuroticism Polygenic Risk in Late Life Cognitive Change: A UK Biobank Study.Behavioral sciences (Basel, Switzerland) · 2024Article
- Life Events and Incident Dementia: A Prospective Study of 493,787 Individuals Over 16 Years.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Association of neuroticism with incident dementia, neuroimaging outcomes, and cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 5 countries.
Funding
Abstract
This study examines whether neuroticism is differentially associated with risk of incident Alzheimer's disease (AD), vascular dementia (VD), and frontotemporal dementia (FTD) using a prospective study design. Participants from the UK Biobank (N = 401,422) completed a self-report neuroticism scale in 2006-2010 and incident all-cause dementia, AD, VD, and FTD were ascertained using electronic health records or death records up to 2018. During an average follow-up of 8.8 years (3,566,123 person-years), there were 1798 incident of all-cause dementia, 675 AD, 376 VD, and 81 FTD. Accounting for age and sex, compared to individuals in the low quartile, individuals in the top quartile of neuroticism had higher risk of all-cause dementia (HR = 1.70; 95% CI: 1.49-1.93), AD (HR = 1.42; 1.15-1.75), VD (HR = 1.73; 1.30-2.29), but not FTD (HR = 0.89; 0.49-1.63). The associations with AD and VD were attenuated but remained significant after further accounting for education, household income, deprivation index, diabetes, hypertension, stroke, heart attack, ever smoker, physical activity, obesity, hemoglobin A1c, C-reactive protein, and low-density lipoprotein. The associations were not moderated by socioeconomic status. The findings were consistent in analyses that excluded cases that occurred within the first 5 years of follow-up. In conclusion, neuroticism is a robust predictor of incident AD and VD, but not FTD. This pattern suggests that the affective symptoms that distinguish dementia types may partly reflect premorbid differences in trait neuroticism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.