Evidence map›Paper›PMID 33819836›Full record

ArticleRedox biology2021

Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONO

Marco Fazzari, Steven R Woodcock, Pascal Rowart, Karina Ricart, Jack R Lancaster, Rakesh Patel, Dario A Vitturi, Bruce A Freeman, Francisco J Schopfer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. The chemical biology of dinitrogen trioxide.Redox biochemistry and chemistry · 2024
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marco FazzariDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, 15261, PA, USA. Electronic address: maf167@pitt.edu.
Steven R WoodcockDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, 15261, PA, USA.
Pascal RowartDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, 15261, PA, USA.
Karina RicartDepartment of Pathology, University of Alabama, 901 19th Street South, Birmingham, 35294, AL, USA.
Jack R LancasterDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, 15261, PA, USA; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Pittsburgh, 15213, PA, USA.
Rakesh PatelDepartment of Pathology, University of Alabama, 901 19th Street South, Birmingham, 35294, AL, USA.
Dario A VitturiDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, 15261, PA, USA; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Pittsburgh, 15213, PA, USA; Center for Critical Care Nephrology, Pittsburgh, 15213, PA, USA.
Bruce A FreemanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, 15261, PA, USA.
Francisco J SchopferDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, 15261, PA, USA; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Pittsburgh, 15213, PA, USA.
University of Pittsburgh · USUniversity of Alabama at Birmingham · US

Funding

Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MORRIS, ALISON · 2011 to 2020
$26.1M
Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Translational StudiesP30DK072506 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALCORN, JOHN F · 2005 to 2017
$12.5M
Formation and metabolism of nitrated fatty acidsR01GM125944 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2018 to 2025
$3.4M
NITRIC OXIDE REGULATION OF VASCULAR OXIDANT INJURYR01HL058115 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 1998 to 2007
$3.3M
Anti-Inflammatory Lipid Mediators in AsthmaR01HL132550 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN, HOLGUIN, FERNANDO · 2016 to 2019
$2.9M
Predominant protective role in hepatic steatosis and obesity by fish oil-derived furansR01DK112854 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2018 to 2021
$1.6M
Protection against sickle cell disease nephropathy by nitrated fatty acidsK01HL133331 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VITTURI, DARIO A · 2016 to 2021
$848k
Protective actions of the anti-inflammatory drug candidate 10-nitro-oleic acid in Parkinson’s diseaseR21NS112787 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DI MAIO, ROBERTO, FAZZARI, MARCO · 2019 to 2019
$430k
NHLBI NIH HHS K01 HL133331NHLBI NIH HHS P01 HL103455NHLBI NIH HHS R01 HL058115NHLBI NIH HHS R01 HL132550NIDDK NIH HHS P30 DK072506NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK112854NIGMS NIH HHS R01 GM125944NINDS NIH HHS R21 NS112787
6 · The paper itself

Abstract

Organic nitrate esters, long-recognized therapies for cardiovascular disorders, have not been detected biologically. We characterize in rat stomach unsaturated fatty acid nitration reactions that proceed by generation of nitro-nitrate intermediates (NO

Indexed as

Fatty AcidsNitratesAnimalsEstersNitro CompoundsNitrogen OxidesRatsEstersFatty AcidsNitratesNitro CompoundsNitrogen OxidesConjugated linoleic acidFatty acid nitroalkeneNitrate esterNitro-conjugated linoleic acidNitro-nitrate-fatty acid

Identifiers

PMID33819836
PMCPMC8049994
OpenAlexW3130816526

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.