ArticleJournal of biomechanics2021
Increasing BMI increases lumbar intervertebral disc deformation following a treadmill walking stress test.
Article in Journal of biomechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Causal links between multi-domain risk factors and intervertebral disc degeneration: a systematic review and meta-analysis of Mendelian randomization studies.BMC musculoskeletal disorders · 2026Pooled it
- Accuracy of machine learning in predicting recurrence risk of lumbar disc herniation after percutaneous endoscopic lumbar discectomy: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2026Pooled it
- Running is associated with intervertebral disc adaptations: a pre-planned secondary analysis of the ASTEROID randomised controlled trial.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Trial
- Association Between Conservative Treatment Modalities and Clinical Outcomes in Patients With Lumbosacral Disc Herniation Following Short Term and Long Term Treatments: A Retrospective Cohort Study.Health science reports · 2026Article
- Human In Vivo Disc Mechanics in Flexion, Extension, and Diurnal Loading With Aging and Degeneration.JOR spine · 2026Article
- BMI as an Independent Determinant of Spinal Alignment in Degenerative Scoliosis.Diagnostics (Basel, Switzerland) · 2026Article
- Association between weight-adjusted waist index and the incidence of low back pain among middle-aged and older adults: a nationwide prospective cohort study in China.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Individual and combined associations of modifiable metabolic health and lifestyle with low back pain, neck pain, and functional limitation: evidence from a nationally cross-sectional study.BMC public health · 2026Article
- Proteomic analysis identifies distinct signaling pathways in lumbar intervertebral disc degeneration between type-2 diabetic and non-diabetic patients.Scientific reports · 2026Article
- Advances in mechanical assessments of in vivo human lumbar spine tissues with noninvasive imaging techniques.npj biomedical innovations · 2026Review
- Effect of body mass index and disc degeneration on lumbar biomechanics after unilateral biportal endoscopy-unilateral laminectomy bilateral decompression for lumbar spinal stenosis: a finite element study.Frontiers in bioengineering and biotechnology · 2026Article
- Comparison of functional outcomes in patients with lumbar canal stenosis with and without obesity treated with lumbar decompression surgery.Frontiers in surgery · 2026Article
- Causal association of education, smoking, sedentary lifestyle and body mass index with disc degeneration: Mendelian randomization.Medicine · 2025Article
- Identifying gait subgroups in low back pain patients with artificial intelligence: implications for individualized interventions.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Detailed Analysis of Back Pain: A Cross-Sectional Study of Epidemiology and Previous Therapies in a German Population.Pain practice : the official journal of World Institute of Pain · 2025Article
- Resting Supine for 45 Minutes Yields Consistent Baseline Lumbar Intervertebral Disc Height in Asymptomatic Participants.Annals of biomedical engineering · 2025Article
- Pear-Shaped Disc as a Risk Factor for Postoperative Sclerotic Modic Changes After Transforaminal Lumbar Interbody Fusion.Orthopaedic surgery · 2025Article
- Global, regional, and national burden of low back pain in postmenopausal women from 1990 to 2021: a comprehensive analysis using data from the Global Burden of Disease Study 2021.Frontiers in endocrinology · 2025Article
- Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases.Bone research · 2024Review
- Validation and Estimation of Obesity-Induced Intervertebral Disc Degeneration through Subject-Specific Finite Element Modelling of Functional Spinal Units.Bioengineering (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
High body mass index (BMI) and obesity have been implicated as risk factors for lumbar degenerative disc disease and low back pain. Despite this, there is limited in vivo data to quantify how obesity influences the mechanical function of intervertebral discs (IVD) in response to activities of daily living. Recently, our lab has developed methodologies to non-invasively measure in vivo IVD deformation resulting from activities of daily living using magnetic resonance (MR) imaging and solid modeling techniques. This pilot study expands on these methodologies to assess how BMI influences IVD deformation following treadmill walking in eight asymptomatic individuals. Ordinary least squares regression analyses revealed a statistically significant relationship between BMI and compressive deformation (strain (%)) in the L5-S1 IVD (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.