Evidence map›Paper›PMID 33819537›Full record

ArticleJournal of the American Academy of Dermatology2021

Mucocutaneous manifestations in children hospitalized with COVID-19.

David Andina-Martinez, Montserrat Nieto-Moro, Jose Antonio Alonso-Cadenas, Juan Añon-Hidalgo, Angela Hernandez-Martin, Esther Perez-Suarez, Isabel Colmenero-Blanco, Maria Isabel Iglesias-Bouza, Julia Cano-Fernandez, Ana Mateos-Mayo and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Academy of Dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. PediatricFrontiers in allergy · 2025
    Article
  5. Cutaneous Manifestations of SARS-CoV-2 Infection.American journal of clinical dermatology · 2022
    Review
  6. COVID-19 Pediatric Dermatology.Dermatologic clinics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

David Andina-MartinezEmergency Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain. Electronic address: david.andina@salud.madrid.org.
Montserrat Nieto-MoroPaediatric Intensive Care Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Jose Antonio Alonso-CadenasEmergency Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Juan Añon-HidalgoPaediatric Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Angela Hernandez-MartinDepartment of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Esther Perez-SuarezEmergency Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Isabel Colmenero-BlancoDepartment of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Maria Isabel Iglesias-BouzaPaediatric Intensive Care Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Julia Cano-FernandezPaediatric Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Ana Mateos-MayoDepartment of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Antonio TorreloDepartment of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Hospital Infantil Universitario Niño Jesús · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCutaneous manifestations in hospitalized children with SARS-CoV-2 have not been studied systematically.

objectiveTo describe the mucocutaneous involvement in pediatric patients with COVID-19 admitted to a pediatric institution in Madrid (Spain), located in a zone reporting among the highest prevalence of COVID-19 in Europe.

methodsA descriptive, analytical study was conducted on a series of 50 children hospitalized with COVID-19 between March 1, 2020, and November 30, 2020.

resultsTwenty-one patients presented with mucocutaneous symptoms: 18 patients with macular and/or papular exanthem, 17 with conjunctival hyperemia, and 9 with red cracked lips or strawberry tongue. Eighteen patients fulfilled criteria for multisystem inflammatory syndrome in children. Patients with mucocutaneous involvement tended to be older and presented to the emergency department with poor general status and extreme tachycardia, higher C-reactive protein and D-dimer levels, and lower lymphocyte counts than patients without skin signs. Mucocutaneous manifestations pose a higher risk of admission to the pediatric intensive care unit (odds ratio, 10.24; 95% confidence interval, 2.23-46.88; P = .003).

conclusionsChildren hospitalized with COVID-19 frequently had mucocutaneous involvement, with most symptoms fulfilling criteria for multisystem inflammatory syndrome in children. Patients with an exanthem or conjunctival hyperemia at admission have a higher probability of pediatric intensive care admission than patients without mucocutaneous symptoms.

Indexed as

ChildChild, PreschoolCOVID-19FemaleHospitalizationHumansInfantMaleMucous MembraneRetrospective StudiesSkin DiseasesSystemic Inflammatory Response SyndromeCOVID-19multisystem inflammatory syndromepediatric dermatologySARS-CoV-2

Identifiers

PMID33819537
PMCPMC8017917
OpenAlexW3149344835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.