Evidence map›Paper›PMID 33819464›Full record

Trial reportThe Journal of pediatrics2021

Attention Test Improvements from a Cluster Randomized Controlled Trial of Caregiver Training for HIV-Exposed/Uninfected Ugandan Preschool Children.

Joseph Ikekwere, Valentine Ucheagwu, Itziar Familiar-Lopez, Alla Sikorskii, Jorem Awadu, Julius Caesar Ojuka, Deborah Givon, Cilly Shohet, Bruno Giordani, Michael J Boivin

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00889395 (Cognitive and Psychosocial Benefits of Caregiver Training for Ugandan HIV Children), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00889395 naunknown statusnot on this map

Cognitive and Psychosocial Benefits of Caregiver Training for Ugandan HIV Children

TypeinterventionalSponsorMakerere UniversityRan2008 to 2011Enrolled120ConditionsHIV, HIV InfectionsArmsMISC training for primary caregivers
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Joseph IkekwereDepartment of Psychiatry, University of Michigan, Ann Arbor, MI.
Valentine UcheagwuDepartment of Psychiatry, University of Michigan, Ann Arbor, MI.
Itziar Familiar-LopezDepartment of Psychiatry, Michigan State University, East Lansing, MI.
Alla SikorskiiDepartment of Psychiatry, Michigan State University, East Lansing, MI.
Jorem AwaduDepartment of Psychiatry, Michigan State University, East Lansing, MI.
Julius Caesar OjukaGlobal Health Uganda, Kampala, Uganda.
Deborah GivonSchool of Education, Bar Ilan University, Ramat-Gan, Israel.
Cilly ShohetSchool of Education, Bar Ilan University, Ramat-Gan, Israel.
Bruno GiordaniDepartment of Psychiatry, University of Michigan, Ann Arbor, MI.
Michael J BoivinDepartment of Psychiatry, University of Michigan, Ann Arbor, MI; Department of Psychiatry, Michigan State University, East Lansing, MI. Electronic address: boivin@msu.edu.
Michigan State University · USUniversity of Michigan–Ann Arbor · USBar-Ilan University · ILWorld Health Organization - Uganda · UG

Funding

Cognitive and Psychosocial Benefit of Caregiver Training for Ugandan HIV ChildrenR34MH082663 · NIMH · MICHIGAN STATE UNIVERSITY · PI BOIVIN, MICHAEL JOSEPH · 2008 to 2010
$600k
NIMH NIH HHS R34 MH082663
6 · The paper itself

Abstract

objectiveTo report vigilance attention outcomes from a cluster randomized controlled trial of early childhood development caregiver training for perinatally HIV-exposed/uninfected preschool-age children in rural Uganda. The Early Childhood Vigilance Test (ECVT) provides a webcam recording of proportion of time a child views an animation periodically moving across a computer screen. STUDY

designSixty mothers/caregivers received biweekly year-long training sessions of the Mediational Intervention for Sensitizing Caregivers (MISC), and 59 mothers received biweekly training about nutrition, hygiene, and health care. Children were tested for attention at baseline, 6 months, and 12 months with the ECVT, in terms of proportion of time spent viewing a 6-minute animation of animals greeting the child and moving across the computer monitor screen. Time viewing the animation were scored by trained observers using ProCoder program for webcam scoring of proportion of time the child faced the animation. Mixed-effects modeling was used to compare ECVT outcomes for the 2 intervention groups.

resultsUnadjusted and adjusted (for age, sex, height, and ECVT at baseline) group differences on ECVT significantly favored the MISC arm at 6 months (P = .03; 95% CI (0.01, 0.11), effect size = 0.46) but not at 12 months. Both groups made significant gains in sustained attention across the year-long intervention (P = .021) with no significant interaction effects between time and treatment arms or sex.

conclusionsCaregiver early childhood development training enhanced attention in at-risk Ugandan children, which can be foundational to improved working memory and learning, and perhaps related to previous language benefits reported for this cohort.

trial registrationClinicaltrials.gov: NCT00889395.

Indexed as

Child DevelopmentCaregiversChild of Impaired ParentsChild, PreschoolCluster AnalysisCognitionHealth EducationHIV InfectionsHumansRural PopulationUgandaAfricaattentionearly childhood developmentHIV exposed but uninfectedmediational intervention to sensitize caregivers (MISC)nutritionwebcam scoring

Identifiers

PMID33819464
PMCPMC8316287
OpenAlexW3143705511

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.