ArticlePloS one2021
Mortality and associated risk factors in patients with blood culture positive sepsis and acute kidney injury requiring continuous renal replacement therapy-A retrospective study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Prediction of acute kidney injury after total aortic arch replacement with postoperative serum lactate: a retrospective cohort study.Renal failure · 2026Article
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- The impact of an ex vivo paediatric renal replacement therapy circuit on antimicrobial concentrations.The Journal of antimicrobial chemotherapy · 2026Article
- Real-world clinical outcomes of macrophage activation-like syndrome and hyperferritinemia in sepsis: a retrospective database analysis.EClinicalMedicine · 2026Article
- Long-term outcomes of ICU-acquired infections with a focus on bloodstream infections: a single-center retrospective registry study.Infection · 2025Article
- Neutrophil-to-Lymphocyte Ratio Predicts Dialysis Timing & Prognosis in Critically Ill Patients.Health science reports · 2025Article
- Epidemiology and outcomes of septic shock in Thai children: a nationwide retrospective study from 2015 to 2022.Critical care (London, England) · 2024Article
- Machine learning-based prediction of in-hospital mortality for critically ill patients with sepsis-associated acute kidney injury.Renal failure · 2024Article
- Impact of P2Y12 inhibitors on clinical outcomes in sepsis-3 patients receiving aspirin: a propensity score matched analysis.BMC infectious diseases · 2024Article
- Impact of severe acute kidney injury on short-term mortality in urosepsis.World journal of urology · 2024Article
- Predicting sepsis in-hospital mortality with machine learning: a multi-center study using clinical and inflammatory biomarkers.European journal of medical research · 2024Article
- Unsupervised clustering identifies sub-phenotypes and reveals novel outcome predictors in patients with dialysis-requiring sepsis-associated acute kidney injury.Annals of medicine · 2023Observational
- Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible Therapies.Toxins · 2023Review
- Diagnostic and Prognostic Roles of C-Reactive Protein, Procalcitonin, and Presepsin in Acute Kidney Injury Patients Initiating Continuous Renal Replacement Therapy.Diagnostics (Basel, Switzerland) · 2023Article
- ROCK2 knockdown alleviates LPS-induced inflammatory injury and apoptosis of renal tubular epithelial cells via the NF-κB/NLRP3 signaling pathway.Experimental and therapeutic medicine · 2022Article
- Article
- Renal Replacement Techniques in Septic Shock.International journal of molecular sciences · 2021Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSeptic acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) carries a mortality risk nearing 50%. Risk factors associated with mortality in AKI patients undergoing CRRT with blood culture positive sepsis remain unclear as sepsis has been defined according to consensus criteria in previous studies.
methodsRisk factors associated with intensive care unit (ICU), 90-day and overall mortality were studied in a retrospective cohort of 126 patients with blood culture positive sepsis and coincident severe AKI requiring CRRT. Comprehensive laboratory and clinical data were gathered at ICU admission and CRRT initiation.
results38 different causative pathogens for sepsis and associated AKI were identified. ICU mortality was 30%, 90-day mortality 45% and one-year mortality 50%. Immunosuppression, history of heart failure, APACHE II and SAPS II scores, C-reactive protein and lactate at CRRT initiation were independently associated with mortality in multivariable Cox proportional hazards models. Blood lactate showed good predictive power for ICU mortality in receiver operating characteristic curve analyses with AUCs of 0.76 (95%CI 0.66-0.85) for lactate at ICU admission and 0.84 (95%CI 0.72-0.95) at CRRT initiation.
conclusionsOur study shows for the first time that lactate measured at CRRT initiation is predictive of ICU mortality and independently associated with overall mortality in patients with blood culture positive sepsis and AKI requiring CRRT. Microbial etiology for septic AKI requiring CRRT is diverse.
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