Evidence map›Paper›PMID 33818892›Full record

ReviewPediatric blood & cancer2021

Advances in radiotherapy technology for pediatric cancer patients and roles of medical physicists: COG and SIOP Europe perspectives.

Chia-Ho Hua, Anthony E Mascia, Enrica Seravalli, Antony J Lomax, Klaus Seiersen, Kenneth Ulin

Open access · bronzeAbstract readReview
In one paragraph

Review in Pediatric blood & cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. The Evolution of Radiation Therapy in Children's Oncology Group Trials, From 1998 to 2025.International journal of radiation oncology, biology, physics · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Non-Oncological Radiotherapy: A Review of Modern Approaches.Journal of personalized medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 4 countries.

Chia-Ho HuaDepartment of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-6642-4004
Anthony E MasciaDepartment of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio.
Enrica SeravalliDepartment of Radiotherapy, University Medical Center Utrecht, The Netherlands.
Antony J LomaxCenter for Proton Therapy, Paul Scherrer Institute, PSI Villigen, Switzerland.
Klaus SeiersenDanish Centre for Particle Therapy, Aarhus, Denmark.
Kenneth UlinDepartment of Radiation Oncology, University of Massachusetts, Worcester, Massachusetts.
Aarhus University · DKPaul Scherrer Institute · CHSt. Jude Children's Research Hospital · USUniversity Medical Center Utrecht · NLUniversity of Cincinnati · USUniversity of Massachusetts Chan Medical School · US

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
IROC: Enhancing local enrolling site radiological data capture capabilities for NCTN trialsU24CA180803 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI Thomas J. FitzGerald, MICHAEL V KNOPP · 2014 to 2026
$116.2M
NCI NIH HHS U10 CA180886NCI NIH HHS U24 CA180803
6 · The paper itself

Abstract

Over the last two decades, rapid technological advances have dramatically changed radiation delivery to children with cancer, enabling improved normal-tissue sparing. This article describes recent advances in photon and proton therapy technologies, image-guided patient positioning, motion management, and adaptive therapy that are relevant to pediatric cancer patients. For medical physicists who are at the forefront of realizing the promise of technology, challenges remain with respect to ensuring patient safety as new technologies are implemented with increasing treatment complexity. The contributions of medical physicists to meeting these challenges in daily practice, in the conduct of clinical trials, and in pediatric oncology cooperative groups are highlighted. Representing the perspective of the physics committees of the Children's Oncology Group (COG) and the European Society for Paediatric Oncology (SIOP Europe), this paper provides recommendations regarding the safe delivery of pediatric radiotherapy. Emerging innovations are highlighted to encourage pediatric applications with a view to maximizing the therapeutic ratio.

Indexed as

ChildEuropeHumansNeoplasmsPractice Guidelines as TopicRadiation OncologyRadiotherapyCOGmedical physicistpediatric cancerradiation therapySIOP

Identifiers

PMID33818892
PMCPMC8030241
OpenAlexW3144191695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.