Evidence map›Paper›PMID 33818884›Full record

ReviewPediatric blood & cancer2021

Neuroblastoma.

Christine Chung, Tom Boterberg, John Lucas, Joseph Panoff, Dominique Valteau-Couanet, Barbara Hero, Rochelle Bagatell, Christine E Hill-Kayser

Open access · bronzeAbstract readReview
In one paragraph

Review in Pediatric blood & cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 2 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.

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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 4 countries.

Christine ChungDepartment of Radiation Oncology, Diablo Valley Oncology and Hematology, Pleasant Hill, California.
Tom BoterbergDepartment of Radiation Oncology Ghent University Hospital, Gent, Belgium.
John LucasDepartment of Radiation Oncology St Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-4139-4160
Joseph PanoffDepartment of Radiation Oncology, Miami Cancer Institute, Baptist Health, South Florida, Florida.
Dominique Valteau-CouanetDepartment of Childhood and Adolescent Cancer Gustave Roussy Cancer Campus, Villejuif-Grand, Paris, France.
Barbara HeroDepartment of Pediatric Hematology and Oncology, University Children's Hospital, Cologne, Germany.ORCID 0000-0003-4129-890X
Rochelle BagatellDepartment of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Christine E Hill-KayserDepartment of Radiation Oncology University of Pennsylvania and the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0002-1993-1185
Children's Hospital of Philadelphia · USBaptist Hospital of Miami · USDiablo Valley College · USGhent University Hospital · BEInstitut Gustave Roussy · FRSt. Jude Children's Research Hospital · USUniversity Hospital Cologne · DE

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

The survival of patients with high-risk neuroblastoma has improved significantly with the use of intensive multimodality treatment regimens, including chemotherapy, surgery, radiation therapy, myeloablative chemotherapy followed by stem cell rescue, and immunotherapy. This report summarizes the current treatment strategies used in the COG and SIOP for children with neuroblastoma. The improved global collaboration and the adoption of a uniform International Neuroblastoma Risk Group Staging System will help facilitate comparison of homogeneous pretreatment cohorts across clinical trials. Future research strategies regarding the indications for and dosages of radiation therapy to the primary and metastatic sites, and the integration of meta-iodobenzyl guanidine therapy into the multimodal treatment program, are discussed.

Indexed as

ChildCombined Modality TherapyHumansNeuroblastomaPrognosisautologous stem cell rescuechemotherapyimmunotherapyMIBGneuroblastomaradiation therapysurgery

Identifiers

PMID33818884
PMCPMC8785544
OpenAlexW4210424404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.