Evidence map›Paper›PMID 33818858›Full record

ArticleNeurogastroenterology and motility2021

Distension-contraction profile of peristalsis in patients with nutcracker esophagus.

Ali Zifan, Kazumasa Muta, Ravinder K Mittal

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06665971 (Effect of Dupilumab on Esophageal Peristaltic Function in Participants with Eosinophilic Esophagitis), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06665971 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Dupilumab on Esophageal Peristaltic Function in Participants with Eosinophilic Esophagitis

TypeinterventionalSponsorUniversity of California, San DiegoRan2024 to 2026Enrolled30ConditionsEosinophilic Esophagitis (EoE)ArmsDupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ali ZifanDivision of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, CA, USA.ORCID 0000-0003-0272-7492
Kazumasa MutaDivision of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, CA, USA.
Ravinder K MittalDivision of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, CA, USA.ORCID 0000-0001-5228-9617
University of San Diego · US

Funding

Novel Electrical Impedance Methodology to Understand Functional DysphagiaR01DK109376 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MITTAL, RAVINDER K. · 2016 to 2020
$2.5M
Novel Electrical Impedance Methodology to Understand Functional DysphagiaR56DK109376 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MITTAL, RAVINDER K., ZIFAN, ALI · 2023 to 2023
$682k
NIDDK NIH HHS R01 DK109376NIDDK NIH HHS R56 DK109376
6 · The paper itself

Abstract

introductionHigh amplitude peristaltic esophageal contractions, that is, nutcracker esophagus, were originally described in association with "angina-like pain" of esophageal origin. However, significant number of nutcracker patients also suffer from dysphagia. High-resolution esophageal manometry (HRM) assesses only the contraction phase of peristalsis. The degree of esophageal distension during peristalsis is a surrogate of relaxation and can be measured from the intraluminal esophageal impedance measurements.

aimsDetermine the amplitude of distension and temporal relationship between distension and contraction during swallow-induced peristalsis in nutcracker patients.

methodsHRM impedance (HRMZ) studies were performed and analyzed in 24 nutcracker and 30 normal subjects in the Trendelenburg position. A custom-built software calculated the numerical data of the amplitudes of distension and contraction, the area under the curve (AUC) of distension and contraction, and the temporal relationship between distension and contraction.

resultsIn normal subjects, the distension peaks similar to contraction traverse sequentially the esophagus. The amplitude of contraction is greater in the nutcracker esophagus but the amplitude of distension and area under the curve of distension are smaller in patients compared to controls. Distension peaks are aligned closely with contraction in normal subjects, but in patients, the bolus travels faster to the distal esophagus, resulting in a smaller time interval between the onset of swallow and distension peak. Receiver operative characteristics (ROC) curve reveals high sensitivity and specificity of the above parameters in patients.

conclusionAbnormalities in the distension phase of peristalsis are a possible mechanism of dysphagia in patients with nutcracker esophagus.

Indexed as

PeristalsisAdultAgedDeglutition DisordersEsophageal Motility DisordersFemaleHumansMaleManometryMiddle AgedMuscle ContractionROC CurveYoung Adultdistension-contraction plotsdysphagiaesophageal distensionesophageal peristalsisnutcracker esophagus

Identifiers

PMID33818858
PMCPMC8490481
OpenAlexW3141817371

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.