ArticleHuman brain mapping2021
The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Adverse childhood experiences and resting state functional connectivity of the triple brain network: a meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Effects of Different Stocking Densities on Growth Performance, Stress Resistance, Antioxidant Capacity and Immunity of Grass Carp.Animals : an open access journal from MDPI · 2026Article
- The rs1360780 Variant ofGenes · 2025Review
- Genetic-Dependent Brain Signatures of Resilience: Interactions among Childhood Abuse, Genetic Risks and Brain Function.bioRxiv : the preprint server for biology · 2024Article
- Implementing Core Genes and an Omnigenic Model for Behaviour Traits Prediction in Genomics.Genes · 2023Review
- Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex.Acta neuropathologica · 2023Article
- Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study.JCPP advances · 2022Article
- The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults.Human brain mapping · 2021Article
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Authors and funding
27 authors at 12 institutions in 7 countries.
Funding
Abstract
Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p < .025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.