ArticleJapanese journal of radiology2021
The correlation between hepatic fat fraction evaluated by dual-energy computed tomography and high-risk coronary plaques in patients with non-alcoholic fatty liver disease.
Article in Japanese journal of radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Metabolic dysfunction-associated steatotic liver disease (MASLD): a new disease category within the steatotic liver disease (SLD) framework.Japanese journal of radiology · 2026Article
- Evaluating the role of pericoronary adipose tissue on coronary artery disease: insights from CCTA on risk assessment, vascular stenosis, and plaque characteristics.Frontiers in cardiovascular medicine · 2024Article
- Clinical applications of artificial intelligence in liver imaging.La Radiologia medica · 2023Review
- Dual-energy CT: minimal essentials for radiologists.Japanese journal of radiology · 2022Review
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Authors and funding
8 authors.
Funding
Abstract
purposeTo determine the relationship between non-alcoholic fatty liver disease (NAFLD) evaluated by a hepatic fat fraction (HFF) using dual-energy computed tomography (DECT) and high-risk coronary plaques (HRP) in NAFLD patients.
methodsWe conducted a matched case-control study involving 172 NAFLD individuals recruited from August 2019 to September 2020. They underwent dual-energy coronary computed tomographic angiography and were classified as no-plaque, HRP negative and HRP positive groups. HFF values were measured using multimaterial decomposition algorithm of DECT, and the differences among three groups were compared. Multiple logistic regression analysis was performed to determine the independent correlation between HFF and HRP. Spearman rank correlation was used to assess the correlations between HFF and multiple variables.
resultsHRP positive group (15.3%) had higher HFF values than no-plaque (6.9%) and HRP negative groups (8.9%) (P < 0.001). After adjusting for confounding variables, the results indicated that HFF was an independent risk factor for HRP (OR 1.93, P < 0.001). Additionally, HFF significantly correlated with coronary artery calcium score, hepatic CT attenuation, epicardial and pericoronary adipose tissue volume, and CT attenuation (all P < 0.001).
conclusionsAs a new imaging marker for the quantification of liver fat, HFF was independently associated with HRP.
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