Evidence map›Paper›PMID 33818662›Full record

ArticleDigestive diseases and sciences2022

Functional Analysis of the Transcriptional Regulator IκB-ζ in Intestinal Homeostasis.

Tomoki Sasaki, Hiroyuki Nagashima, Atsushi Okuma, Takeshi Yamauchi, Kenshi Yamasaki, Setsuya Aiba, Takanori So, Naoto Ishii, Yuji Owada, Takashi MaruYama and 1 more

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Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Tomoki SasakiLaboratory of Cell Recognition and Response, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Hiroyuki NagashimaDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Atsushi OkumaLaboratory of Cell Recognition and Response, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Takeshi YamauchiDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kenshi YamasakiDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Setsuya AibaDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takanori SoDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Naoto IshiiDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yuji OwadaDepartment of Organ Anatomy, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi, Japan.
Takashi MaruYamaLaboratory of Cell Recognition and Response, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Shuhei KobayashiLaboratory of Cell Recognition and Response, Graduate School of Life Sciences, Tohoku University, Sendai, Japan. s_kobayashi@med.tohoku.ac.jp.ORCID 0000-0002-1019-8669
Tohoku University · JPNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Toll-like receptor signaling pathway contributes to the regulation of intestinal homeostasis through interactions with commensal bacteria. Although the transcriptional regulator IκB-ζ can be induced by Toll-like receptor signaling, its role in intestinal homeostasis is still unclear.

aimsTo investigate the role of IκB-ζ in gut homeostasis.

methodsDSS-administration induced colitis in control and IκB-ζ-deficient mice. The level of immunoglobulins in feces was detected by ELISA. The immunological population in lamina propria (LP) was analyzed by FACS.

resultsIκB-ζ-deficient mice showed severe inflammatory diseases with DSS administration in the gut. The level of IgM in the feces after DSS administration was less in IκB-ζ-deficient mice compared to control mice. Upon administration of DSS, IκB-ζ-deficient mice showed exaggerated intestinal inflammation (more IFN-g-producing CD4

conclusionIκB-ζ plays a crucial role in maintaining homeostasis in the gut.

Indexed as

ColitisAnimalsDextran SulfateHomeostasisHumansInterferon-gammaIntestinal MucosaMiceMice, Inbred C57BLSignal TransductionDextran SulfateInterferon-gammaGut homeostasisInflammatory bowel disease (IBD)IκB-ζ

Identifiers

PMID33818662
OpenAlexW3152409562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.