ArticleNeural regeneration research2021
Apelin-13 regulates electrical activity in the globus pallidus and induces postural changes in rats.
Article in Neural regeneration research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The Mechanism of the Nucleus Accumbens-Ventral Pallidum Pathway Mediated by Drug Withdrawal-Induced High-Seeking Motivation in Cocaine Addiction.International journal of molecular sciences · 2024Article
- Beneficial effects of Apelin-13 on metabolic diseases and exercise.Frontiers in endocrinology · 2023Review
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Authors and funding
4 authors.
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Abstract
The globus pallidus is the relay nucleus of the basal ganglia, and changes in its electrical activity can cause motor impairment. Apelin-13 is widely distributed in the central and peripheral nervous systems. It has been demonstrated that apelin-13 plays important roles in the regulation of blood pressure and other non-motor functions. However, its role in motor function has rarely been reported. In the present study, apelin-13 (10 μM/100 μM) was injected into the globus pallidus of rats. The results showed that apelin-13 increased the spontaneous discharges in the majority of pallidal neurons. However, an apelin-13-induced inhibitory effect on the firing rate was also observed in a few pallidal neurons. In postural tests, after the systemic administration of haloperidol, unilateral pallidal injection of apelin-13 caused a contralateral deflection. Together, these findings suggest that apelin-13 regulates the electrical activity of pallidal neurons and thus participates in central motor control in rats. The study was approved by the Animal Ethics Committee of Qingdao University (approval No. 20200615Wistar0451003020) on June 15, 2020.
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