Evidence map›Paper›PMID 33818294›Full record

ArticleEpigenetics2022

Epigenome-wide analysis of long-term air pollution exposure and DNA methylation in monocytes: results from the Multi-Ethnic Study of Atherosclerosis.

Gloria C Chi, Yongmei Liu, James W MacDonald, Lindsay M Reynolds, Daniel A Enquobahrie, Annette L Fitzpatrick, Kathleen F Kerr, Matthew J Budoff, Su-In Lee, David Siscovick and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. DNA Methylation Patterns Associated with Tinnitus in Young Adults-A Pilot Study.Journal of the Association for Research in Otolaryngology : JARO · 2024
    Article
  7. Article
  8. Epigenomic insights into common human disease pathology.Cellular and molecular life sciences : CMLS · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Gloria C ChiDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Yongmei LiuDepartment of Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
James W MacDonaldDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-7328-7626
Lindsay M ReynoldsDepartment of Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Daniel A EnquobahrieDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Annette L FitzpatrickDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Kathleen F KerrDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA.
Matthew J BudoffDivision of Cardiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Su-In LeeDepartment of Computer Science & Engineering, University of Washington, Seattle, Washington, USA.
David SiscovickNew York Academy of Medicine, New York, New York, USA.
Joel D KaufmanDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
University of Washington · USWake Forest University · USNew York Academy of Medicine · USThe Lundquist Institute · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Project 5: ROS, Glutathione and Vascular Response to Diesel ExhaustP50ES015915 · NIEHS · UNIVERSITY OF WASHINGTON · PI KAVANAGH, TERRANCE J · 2008 to 2012
$11.8M
Neighborhoods and CVD Risk in a Multiethnic Cohort (RMI)R01HL071759 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ ROUX, ANA VICTORIA · 2003 to 2013
$4.8M
Epigenome-Wide Association Study of DNA Methylation and AtherosclerosisR01HL101250 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LIU, YONGMEI · 2009 to 2013
$3.6M
CVD Epidemiology Training ProgramT32HL007902 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 1998 to 2012
$3.6M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Environmental Factors in Cardiovascular DiseaseK24ES013195 · NIEHS · UNIVERSITY OF WASHINGTON · PI KAUFMAN, JOEL DANIEL · 2005 to 2014
$1.5M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL071759NHLBI NIH HHS R01 HL101250NHLBI NIH HHS T32 HL007902NIEHS NIH HHS F31 ES025475NIEHS NIH HHS K24 ES013195NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P50 ES015915
6 · The paper itself

Abstract

Air pollution might affect atherosclerosis through DNA methylation changes in cells crucial to atherosclerosis, such as monocytes. We conducted an epigenome-wide study of DNA methylation in CD14+ monocytes and long-term ambient air pollution exposure in adults participating in the Multi-Ethnic Study of Atherosclerosis (MESA). We also assessed the association between differentially methylated signals and

Indexed as

Air PollutantsAir PollutionAtherosclerosisAdultAntigens, NeoplasmDNA MethylationEnvironmental ExposureEpigenomeHumansMonocytesNeoplasm ProteinsParticulate MatterAir PollutantsAntigens, NeoplasmARID4B protein, humanNeoplasm ProteinsParticulate MatterAir pollutionDNA methylationfine particulate mattergene expressionoxides of nitrogen

Identifiers

PMID33818294
PMCPMC8920186
OpenAlexW3143676854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.