Evidence map›Paper›PMID 33818125›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Expression and function of human ribonuclease 4 in the kidney and urinary tract.

Kristin Bender, Laura L Schwartz, Ariel Cohen, Claudia Mosquera Vasquez, Matthew J Murtha, Tad Eichler, Jason P Thomas, Ashley Jackson, John David Spencer

Open access · greenAbstract readHistorical Article
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Circulating proteomic biomarkers for cerebral amyloid angiopathy screening and risk stratification.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Insulin receptor orchestrates kidney antibacterial defenses.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Intercalated cell function, kidney innate immunity, and urinary tract infections.Pflugers Archiv : European journal of physiology · 2024
    Review
  13. Article
  14. A Common Polymorphism inInternational journal of molecular sciences · 2024
    Article
  15. Article
  16. Uropathogen and host responses in pyelonephritis.Nature reviews. Nephrology · 2023
    Review
  17. Article
  18. Immune defenses in the urinary tract.Trends in immunology · 2023
    Review
  19. Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kristin BenderNephrology and Urology Research Affinity Group, Nationwide Children's Hospital, Columbus, Ohio.
Laura L SchwartzNephrology and Urology Research Affinity Group, Nationwide Children's Hospital, Columbus, Ohio.
Ariel CohenNephrology and Urology Research Affinity Group, Nationwide Children's Hospital, Columbus, Ohio.
Claudia Mosquera VasquezNephrology and Urology Research Affinity Group, Nationwide Children's Hospital, Columbus, Ohio.
Matthew J MurthaNephrology and Urology Research Affinity Group, Nationwide Children's Hospital, Columbus, Ohio.
Tad EichlerNephrology and Urology Research Affinity Group, Nationwide Children's Hospital, Columbus, Ohio.
Jason P ThomasNephrology and Urology Research Affinity Group, Nationwide Children's Hospital, Columbus, Ohio.
Ashley JacksonNephrology and Urology Research Affinity Group, Nationwide Children's Hospital, Columbus, Ohio.
John David SpencerNephrology and Urology Research Affinity Group, Nationwide Children's Hospital, Columbus, Ohio.ORCID 0000-0001-5509-7135
Nationwide Children's Hospital · US

Funding

The Contributions of Ribonuclease 4 & 7 to Urinary Tract Antibacterial DefenseR01DK115737 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI John David Spencer · 2018 to 2026
$2.8M
Insulin Signaling Activates Urothelial Defenses to Reduce Urinary Tract Infection SusceptibilityR01DK128088 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI SPENCER, JOHN DAVID · 2021 to 2025
$2.6M
Linking Insulin Signaling to Antimicrobial Peptide Production and the Kidney's Antibacterial DefensesR01DK114035 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI SPENCER, JOHN DAVID · 2018 to 2021
$1.4M
NIDDK NIH HHS R01 DK114035NIDDK NIH HHS R01 DK115737NIDDK NIH HHS R01 DK128088
6 · The paper itself

Abstract

Antimicrobial peptides are essential host defense mechanisms that prevent urinary tract infections. Recent studies have demonstrated that peptides in the ribonuclease A superfamily have antimicrobial activity against uropathogens and protect the urinary tract from uropathogenic

Indexed as

AdolescentAntimicrobial Cationic PeptidesChildEndothelial CellsFemaleGene Expression Regulation, EnzymologicGene SilencingHistory, AncientHistory, MedievalHumansKidneyReal-Time Polymerase Chain ReactionRibonucleasesUrinary BladderUropathogenic Escherichia coliUrotheliumAntimicrobial Cationic Peptidesribonuclease 4Ribonucleasesantimicrobial peptidesbladderinnate immunitykidneyribonuclease 4urinary tract infection

Identifiers

PMID33818125
PMCPMC8174806
OpenAlexW3146685985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.